Drug Information

Drug General Information
Drug ID
D03QWT
Former ID
DCL000778
Drug Name
Doripenem
Synonyms
Doribax; S 4661; S-4661; Doripenem (USAN/INN); (4R,5S,6S)-6-[(1R)-1-hydroxyethyl]-4-methyl-7-oxo-3-[(3S,5S)-5-[(sulfamoylamino)methyl]pyrrolidin-3-yl]sulfanyl-1-azabicyclo[3.2.0]hept-2-ene-2-carboxylic acid
Drug Type
Small molecular drug
Indication Urinary tract infections [ICD9: 599; ICD10:N39.0] Approved [529282], [533123]
Gram-positive bacterial infection [ICD9:] Phase 3 [536094]
Company
Shionogi; penisula
Structure
Download
2D MOL

3D MOL
Formula
C15H24N4O6S2
Canonical SMILES
CC1C2C(C(=O)N2C(=C1SC3CC(NC3)CNS(=O)(=O)N)C(=O)O)C(C)O
InChI
1S/C15H24N4O6S2/c1-6-11-10(7(2)20)14(21)19(11)12(15(22)23)13(6)26-9-3-8(17-5-9)4-18-27(16,24)25/h6-11,17-18,20H,3-5H2,1-2H3,(H,22,23)(H2,16,24,25)/t6-,7-,8+,9+,10-,11-/m1/s1
InChIKey
AVAACINZEOAHHE-VFZPANTDSA-N
CAS Number
CAS 148016-81-3
PubChem Compound ID
73303
PubChem Substance ID
8195661, 14782518, 14904822, 17397979, 43129277, 50112763, 57319033, 78931074, 99299161, 103596434, 104354952, 118047125, 126665586, 134339262, 135030316, 136367963, 137103545, 140972593, 144115919, 144206061, 152057781, 152344294, 164824831, 170465085, 174527594, 175266776, 175437740, 179117027, 184547713, 210279313, 210281636, 223556613, 223659794, 226423250, 241037251, 242439235, 249358056, 249583208, 249822520, 251963975, 251970995, 252215304, 252348782
SuperDrug ATC ID
J01DH04
Target and Pathway
Target(s) Dihydropteroate synthetase Target Info Inhibitor [536094]
References
Ref 5292822007 FDA drug approvals: a year of flux. Nat Rev Drug Discov. 2008 Feb;7(2):107-9.
Ref 5331232014 FDA drug approvals. Nat Rev Drug Discov. 2015 Feb;14(2):77-81.
Ref 536094Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.
Ref 536094Emerging drugs for bacterial urinary tract infections. Expert Opin Emerg Drugs. 2005 May;10(2):275-98.

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