Drug General Information
Drug ID
D03RGP
Former ID
DNC011406
Drug Name
(R,S)-AMPA
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529714]
Structure
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2D MOL

3D MOL

Formula
C7H10N2O4
Canonical SMILES
CC1=C(C(=O)NO1)CC(C(=O)O)N
InChI
1S/C7H10N2O4/c1-3-4(6(10)9-13-3)2-5(8)7(11)12/h5H,2,8H2,1H3,(H,9,10)(H,11,12)
InChIKey
UUDAMDVQRQNNHZ-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Glutamate receptor AMPA subtype Target Info Inhibitor [529714]
Glutamate receptor, ionotropic kainate 1 Target Info Inhibitor [529714]
Glutamate receptor 1 Target Info Inhibitor [529714]
KEGG Pathway Neuroactive ligand-receptor interaction
Glutamatergic synapsehsa04024:cAMP signaling pathway
Circadian entrainment
Long-term potentiation
Retrograde endocannabinoid signaling
Glutamatergic synapse
Dopaminergic synapse
Long-term depression
Amyotrophic lateral sclerosis (ALS)
Amphetamine addiction
Nicotine addiction
PANTHER Pathway Huntington disease
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathwayP00037:Ionotropic glutamate receptor pathway
Pathway Interaction Database EPHB forward signaling
Reactome COPII (Coat Protein 2) Mediated Vesicle Transport
Trafficking of AMPA receptors
Trafficking of GluR2-containing AMPA receptors
Unblocking of NMDA receptor, glutamate binding and activation
Cargo concentration in the ER
WikiPathways Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic CellWP666:Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Amyotrophic lateral sclerosis (ALS)
BDNF signaling pathway
References
Ref 529714J Med Chem. 2008 Oct 23;51(20):6614-8. Epub 2008 Sep 24.1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators.
Ref 529714J Med Chem. 2008 Oct 23;51(20):6614-8. Epub 2008 Sep 24.1H-cyclopentapyrimidine-2,4(1H,3H)-dione-related ionotropic glutamate receptors ligands. structure-activity relationships and identification of potent and Selective iGluR5 modulators.

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