| Drug General Information |
| Drug ID |
D03SNI
|
| Former ID |
DNC008438
|
| Drug Name |
VUF-10148
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C20H22N4
|
| Canonical SMILES |
CN1CCN(CC1)C2=NC3=CC=CC=C3N=C2CC4=CC=CC=C4
|
| InChI |
1S/C20H22N4/c1-23-11-13-24(14-12-23)20-19(15-16-7-3-2-4-8-16)21-17-9-5-6-10-18(17)22-20/h2-10H,11-15H2,1H3
|
| InChIKey |
PQQUQVYOCGJWAX-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Histamine H2 receptor |
Target Info |
Inhibitor |
[1]
|
|---|
| Histamine H1 receptor |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
Calcium signaling pathway
|
|
Neuroactive ligand-receptor interaction
|
|
Gastric acid secretionhsa04020:Calcium signaling pathway
|
|
Inflammatory mediator regulation of TRP channels
|
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PANTHER Pathway
|
Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
|
|
Histamine H2 receptor mediated signaling pathwayP04385:Histamine H1 receptor mediated signaling pathway
|
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PathWhiz Pathway
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Intracellular Signalling Through Histamine H2 Receptor and Histamine
|
|
Gastric Acid Production
|
|
Reactome
|
Histamine receptors
|
|
G alpha (s) signalling eventsR-HSA-390650:Histamine receptors
|
|
G alpha (q) signalling events
|
|
WikiPathways
|
Monoamine GPCRs
|
|
GPCRs, Class A Rhodopsin-like
|
|
Secretion of Hydrochloric Acid in Parietal Cells
|
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GPCR ligand binding
|
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GPCR downstream signalingWP58:Monoamine GPCRs
|
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IL-4 Signaling Pathway
|
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Gastrin-CREB signalling pathway via PKC and MAPK
|
|
GPCR downstream signaling
|
| References |
| REF 1 | J Med Chem. 2008 Apr 24;51(8):2457-67. Epub 2008 Mar 22.Fragment based design of new H4 receptor-ligands with anti-inflammatory properties in vivo. |
|---|
