Drug Information
Drug General Information | |||||
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Drug ID |
D03SWH
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Former ID |
DIB001834
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Drug Name |
PNU-142633
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Drug Type |
Small molecular drug
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Indication | Migraine [ICD9: 346; ICD10:G43] | Discontinued in Phase 2 | [547202] | ||
Company |
Pharmacia & Upjohn Inc
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Structure |
Download2D MOL |
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Formula |
C24H30N4O3
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Canonical SMILES |
N1(c2ccc(C(=O)N)cc2)CCN(CC[C@H]2c3c(cc(C(=O)NC)cc3)CCO2<br />)CC1
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CAS Number |
CAS 187665-65-2
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PubChem Compound ID | |||||
Target and Pathway | |||||
Target(s) | 5-hydroxytryptamine 1D receptor | Target Info | Agonist | [526906], [551730] | |
References | |||||
Ref 526906 | Further characterization of the 5-HT1 receptors mediating cardiac sympatho-inhibition in pithed rats: pharmacological correlation with the 5-HT1B and 5-HT1D subtypes. Naunyn Schmiedebergs Arch Pharmacol. 2004 Feb;369(2):220-7. Epub 2003 Dec 12. | ||||
Ref 551730 | Sustained pain relief with dihydroergotamine in migraine is potentially due to persistent binding to 5-HT1B and 5-HT1D receptors. . The Journal of Headache and Pain 201314(Suppl 1):P75. |
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