Drug Information

Drug General Information
Drug ID
D03YIO
Former ID
DNC002455
Drug Name
Adenosine-5'-[Beta, Gamma-Methylene]Triphosphate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [551393]
Structure
Download
2D MOL
Formula
C11H18N5O12P3
Canonical SMILES
C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(CP(=O<br />)(O)O)O)O)O
InChI
1S/C11H18N5O12P3/c12-9-6-10(14-2-13-9)16(3-15-6)11-8(18)7(17)5(27-11)1-26-31(24,25)28-30(22,23)4-29(19,20)21/h2-3,5,7-8,11,17-18H,1,4H2,(H,22,23)(H,24,25)(H2,12,13,14)(H2,19,20,21)/t5-,7-,8-,11-/m1/s1
InChIKey
UFZTZBNSLXELAL-IOSLPCCCSA-N
PubChem Compound ID
91532
PubChem Substance ID
586330, 820361, 822395, 822415, 822419, 822440, 822540, 823353, 824010, 824286, 825729, 825731, 828294, 831722, 832838, 837798, 854758, 855363, 7838931, 7885692, 8009903, 8023196, 10224862, 10317456, 11110034, 11538286, 11538290, 14709984, 14710014, 14710554, 15047277, 15382394, 22394507, 22394514, 24277183, 24697975, 24771060, 24771070, 24778912, 24874890, 26704341, 26704344, 26706102, 26706104, 26716517, 26737160, 26737176, 26737189, 26737208, 26744211
Target and Pathway
Target(s) Insulin receptor Target Info Inhibitor [551393]
Pyridoxal kinase Target Info Inhibitor [551393]
BioCyc Pathway Pyridoxal 5'-phosphate salvage
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
cGMP-PKG signaling pathway
HIF-1 signaling pathway
FoxO signaling pathway
PI3K-Akt signaling pathway
AMPK signaling pathway
Adherens junction
Insulin signaling pathway
Ovarian steroidogenesis
Type II diabetes mellitus
Non-alcoholic fatty liver disease (NAFLD)
Aldosterone-regulated sodium reabsorptionhsa00750:Vitamin B6 metabolism
Metabolic pathways
NetPath Pathway TGF_beta_Receptor Signaling PathwayNetPath_25:FSH Signaling Pathway
PANTHER Pathway Insulin/IGF pathway-mitogen activated protein kinase kinase/MAP kinase cascade
Insulin/IGF pathway-protein kinase B signaling cascade
PI3 kinase pathwayP02770:Pyridoxal phosphate salvage pathway
Vitamin B6 metabolism
Pathway Interaction Database Insulin Pathway
Signaling events mediated by PTP1B
Signaling events mediated by TCPTP
Insulin-mediated glucose transport
PathWhiz Pathway Insulin Signalling
Leucine Stimulation on Insulin SignalingPW000053:Vitamin B6 Metabolism
Reactome IRS activation
Signal attenuation
Insulin receptor signalling cascade
Insulin receptor recycling
WikiPathways DNA Damage Response (only ATM dependent)
Insulin Signaling
Nanoparticle triggered autophagic cell death
AGE/RAGE pathway
Signaling by Insulin receptor
Folate Metabolism
Type II diabetes mellitus
Vitamin B12 Metabolism
Selenium Micronutrient Network
AMPK SignalingWP1857:Metabolism of water-soluble vitamins and cofactors
References
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.
Ref 551393How many drug targets are there? Nat Rev Drug Discov. 2006 Dec;5(12):993-6.

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