Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D03ZKE
|
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| Former ID |
DCL000759
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| Drug Name |
CS-003
|
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| Drug Type |
Small molecular drug
|
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| Indication | Chronic obstructive pulmonary disease [ICD9: 490-492, 494-496; ICD10:J40-J44, J47] | Discontinued in Phase 2 | [1] | ||
| Company |
Sankyo
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C35H39Cl2NO6S
|
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| Canonical SMILES |
COC1=CC(=CC(=C1OC)OC)C(=O)N2CCOCC2(CCC3CCC4(CC3)C5=CC=C<br />C=C5CS4=O)C6=CC(=C(C=C6)Cl)Cl
|
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| InChI |
1S/C35H39Cl2NO6S/c1-41-30-18-25(19-31(42-2)32(30)43-3)33(39)38-16-17-44-22-34(38,26-8-9-28(36)29(37)20-26)13-10-23-11-14-35(15-12-23)27-7-5-4-6-24(27)21-45(35)40/h4-9,18-20,23H,10-17,21-22H2,1-3H3/t23?,34-,35?,45?/m1/s1
|
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| InChIKey |
ZNZYXGOBVCQIIG-WANOBJFPSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | NK-2 receptor | Target Info | Antagonist | [1] | |
| Substance-P receptor | Target Info | Antagonist | [1] | ||
| Nigral tachykinin NK(3) receptor | Target Info | Antagonist | [1] | ||
| KEGG Pathway | Calcium signaling pathway | ||||
| Neuroactive ligand-receptor interactionhsa04020:Calcium signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Measleshsa04020:Calcium signaling pathway | |||||
| PANTHER Pathway | CCKR signaling map ST | ||||
| Reactome | G alpha (q) signalling eventsR-HSA-416476:G alpha (q) signalling eventsR-HSA-416476:G alpha (q) signalling events | ||||
| WikiPathways | Gastrin-CREB signalling pathway via PKC and MAPK | ||||
| Peptide GPCRs | |||||
| GPCR ligand binding | |||||
| GPCR downstream signalingWP706:SIDS Susceptibility Pathways | |||||
| Spinal Cord Injury | |||||
| GPCR downstream signalingWP2664:Gastrin-CREB signalling pathway via PKC and MAPK | |||||
| GPCR downstream signaling | |||||
| References | |||||
| REF 1 | Emerging drugs for the treatment of chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2006 May;11(2):275-91. | ||||
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