Drug Information

Drug General Information
Drug ID
D03ZPX
Former ID
DIB009459
Drug Name
PRX-07034
Synonyms
5-HT 6 antagonists (obesity/cognitive impairment), EPIX; 5-HT 6 antagonists (obesity/cognitive impairment), Predix
Drug Type
Small molecular drug
Indication Obesity [ICD9: 278; ICD10:E66] Phase 1 [548037]
Company
Epix Pharmaceutical
Structure
Download
2D MOL

3D MOL
Formula
C21H29Cl2N3O4S
Canonical SMILES
c1c(c(c(cc1Cl)C(C)Nc1c(ccc(c1)N1CCNCC1)S(=O)(=O)C)OC)OC<br />.Cl
PubChem Compound ID
23653584
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Antagonist [533042]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 548037Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800021329)
Ref 533042Low-dose prazosin in combination with 5-HT6 antagonist PRX-07034 has antipsychotic effects. Can J Physiol Pharmacol. 2015 Jan;93(1):13-21.

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