Drug Information

Drug General Information
Drug ID
D04AQE
Former ID
DNC004868
Drug Name
5-METHOXYTRYPTAMINE
Drug Type
Small molecular drug
Indication Discovery agent Investigative [538652]
Structure
Download
2D MOL

3D MOL
Formula
C11H14N2O
InChI
InChI=1S/C11H14N2O/c1-14-9-2-3-11-10(6-9)8(4-5-12)7-13-11/h2-3,6-7,13H,4-5,12H2,1H3
InChIKey
JTEJPPKMYBDEMY-UHFFFAOYSA-N
PubChem Compound ID
1833
PubChem Substance ID
7970, 105814, 803909, 3133821, 5496811, 7636332, 7736866, 8151307, 10529440, 11111484, 11152249, 11363087, 11365649, 11368211, 11374263, 11376373, 11484978, 11488927, 11492417, 11494007, 14719328, 15171512, 24286968, 24857245, 24883984, 26755698, 26755699, 29221032, 41877487, 46387021, 46530516, 47440450, 47810946, 48035326, 48035327, 48185165, 49748019, 49748020, 49829958, 49983314, 50111152, 53795942, 57321043, 57565614, 58023683, 77137071, 81040761, 81049398, 81065577, 85087623
Target and Pathway
Target(s) 5-hydroxytryptamine 6 receptor Target Info Inhibitor [527474]
5-hydroxytryptamine 2A receptor Target Info Inhibitor [533464]
TRPM8 protein Target Info Inhibitor [531228]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04020:Calcium signaling pathway
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04750:Inflammatory mediator regulation of TRP channels
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathwayP04374:5HT2 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 6 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling eventsR-HSA-3295583:TRP channels
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
SIDS Susceptibility Pathways
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR downstream signaling
GPCRs, Other
References
Ref 538652(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 107).
Ref 527474J Med Chem. 2005 Mar 24;48(6):1781-95.Medicinal chemistry driven approaches toward novel and selective serotonin 5-HT6 receptor ligands.
Ref 531228Bioorg Med Chem Lett. 2010 Dec 1;20(23):7076-9. Epub 2010 Sep 22.5-benzyloxytryptamine as an antagonist of TRPM8.
Ref 533464J Med Chem. 1987 Jan;30(1):1-12.Central serotonin receptors as targets for drug research.

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