TTD | Drug: D04AWZ

Drug General Information
Drug ID	D04AWZ
Former ID	DNC004050
Drug Name	SB-201146
Drug Type	Small molecular drug
Indication	Discovery agent		Terminated	[545581]
Structure		Download 2D MOL 3D MOL
Formula	C30H36N2O5S
Canonical SMILES	[Li+].COC1=CC=C(C=C1)CCCCCCCCOC2=C(N=C(C=C2)CS(=O)C3=CC<br />=CC(=C3)N)C=CC(=O)[O-]
InChI	1S/C30H36N2O5S.Li/c1-36-26-15-12-23(13-16-26)9-6-4-2-3-5-7-20-37-29-18-14-25(32-28(29)17-19-30(33)34)22-38(35)27-11-8-10-24(31)21-27;/h8,10-19,21H,2-7,9,20,22,31H2,1H3,(H,33,34);/q;+1/p-1/b19-17+;
InChIKey	RVRATNAADXHAQO-ZJSKVYKZSA-M
PubChem Compound ID	6439436
Target and Pathway
Target(s)	Leukotriene B4 receptor 1	Target Info	Inhibitor	[534210]
KEGG Pathway	Neuroactive ligand-receptor interaction
NetPath Pathway	IL4 Signaling Pathway
Reactome	Leukotriene receptors
Reactome	G alpha (q) signalling events
WikiPathways	Nucleotide GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	Spinal Cord Injury
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 545581	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800003774)
Ref 534210	J Med Chem. 1996 Sep 13;39(19):3837-41.(E)-3-[6-[[(2,6-dichlorophenyl)thio]methyl]-3-(2-phenylethoxy)-2- pyridinyl]-2-propenoic acid: a high-affinity leukotriene B4 receptor antagonist with oral antiinflammatory activity.

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Drug Information