Drug General Information
Drug ID	D04BSZ
Former ID	DIB010673
Drug Name	PD-0204318
Synonyms	PD-0183764
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Terminated	[547298]
Company	Parke-Davis & Co
Structure		Download 2D MOL 3D MOL
Canonical SMILES	N(CC=C(C)C)(C1CCN(CC1)Cc1ccc(N(C)C)cc1)c1ccc(cc1)CCC(C)<br />(C)C
CAS Number	CAS 241499-17-2
Target and Pathway
Target(s)	Voltage-dependent N-type calcium channel	Target Info	Antagonist	[550906]
KEGG Pathway	MAPK signaling pathway
	Calcium signaling pathway
	Synaptic vesicle cycle
	Retrograde endocannabinoid signaling
	Cholinergic synapse
	Serotonergic synapse
	GABAergic synapse
	Dopaminergic synapse
	Taste transduction
	Type II diabetes mellitus
	Morphine addiction
	Nicotine addiction
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
	Ionotropic glutamate receptor pathway
	Metabotropic glutamate receptor group III pathway
	Metabotropic glutamate receptor group II pathway
	Thyrotropin-releasing hormone receptor signaling pathway
	Endogenous cannabinoid signaling
	GABA-B receptor II signaling
Reactome	Depolarization of the Presynaptic Terminal Triggers the Opening of Calcium Channels
WikiPathways	Calcium Regulation in the Cardiac Cell
	Synaptic Vesicle Pathway
References
Ref 547298	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800014952)
Ref 550906	US patent application no. 2012,0172,429, Permanently charged sodium and calcium channel blockers as anti- inflammatory agents.

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