Drug Information

Drug General Information
Drug ID
D04DHB
Former ID
DNC002627
Drug Name
5,7-Dichlorokynurenic Acid
Synonyms
Dcka
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539500]
Structure
Download
2D MOL

3D MOL
Formula
C10H5Cl2NO3
InChI
InChI=1S/C10H5Cl2NO3/c11-4-1-5(12)9-6(2-4)13-7(10(15)16)3-8(9)14/h1-3H,(H,13,14)(H,15,16)
InChIKey
BGKFPRIGXAVYNX-UHFFFAOYSA-N
PubChem Compound ID
1779
PubChem Substance ID
829402, 5171925, 7887060, 7978605, 8151276, 11111036, 11113436, 11342031, 11362214, 11364349, 11366911, 11369473, 11372731, 11373489, 11377635, 11485953, 11487616, 11489815, 11491551, 11491900, 11495269, 14750071, 17405001, 24277976, 26612288, 26679828, 26747105, 26751671, 29220979, 46392865, 46504992, 47216954, 47216955, 47216956, 47291299, 47589164, 47736680, 48105115, 48253870, 50064333, 50104367, 50104368, 50104369, 53777544, 57321018, 75966442, 85230995, 85787785, 90341603, 91579095
Target and Pathway
Target(s) NMDA receptor subunit NR1 Target Info Inhibitor [551374]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Cocaine addiction
Amphetamine addiction
Nicotine addiction
Alcoholism
PANTHER Pathway Huntington disease
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Reactome EPHB-mediated forward signaling
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
RAF/MAP kinase cascade
WikiPathways SIDS Susceptibility Pathways
Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Spinal Cord Injury
BDNF signaling pathway
Alzheimers Disease
References
Ref 539500(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2361).
Ref 551374The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.