Drug General Information
Drug ID
D04DMO
Former ID
DIB005811
Drug Name
FR-194738
Drug Type
Small molecular drug
Indication Hypercholesterolemia [ICD10:E78] Terminated [546677]
Company
Fujisawa Pharmaceutical Co Ltd
Structure
Download
2D MOL

3D MOL

Formula
C27H38ClNO2S
Canonical SMILES
C(#CC(C)(C)C)/C=C/CN(Cc1cc(OCC(OCc2cscc2)(C)C)ccc1)CC.C<br />l
CAS Number
CAS 204067-52-7
PubChem Compound ID
Target and Pathway
Target(s) Squalene monooxygenase Target Info Modulator [526940]
KEGG Pathway Steroid biosynthesis
Sesquiterpenoid and triterpenoid biosynthesis
Metabolic pathways
Biosynthesis of secondary metabolites
Biosynthesis of antibiotics
PathWhiz Pathway Steroid Biosynthesis
Reactome Cholesterol biosynthesis
Activation of gene expression by SREBF (SREBP)
References
Ref 546677Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009590)
Ref 526940Synthesis and biological activity of a novel squalene epoxidase inhibitor, FR194738. Bioorg Med Chem Lett. 2004 Feb 9;14(3):633-7.

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