Drug Information

Drug General Information
Drug ID
D04EFK
Former ID
DCL000766
Drug Name
DDP-225
Synonyms
AA-10021; AA-10025; AA-10026; 4-(2-fluorophenyl)-6-methyl-2-piperazin-1-ylthieno[2,3-d]pyrimidine hydrate hydrochloride
Drug Type
Small molecular drug
Indication Irritable bowel syndrome [ICD9: 564.1, 787.91; ICD10:A09, K58, K59.1] Phase 2 [536224]
Chronic functional vomiting [ICD9: 536.2; ICD10:R11.10] Discontinued in Phase 2 [536224]
Company
Dynogen
Structure
Download
2D MOL

3D MOL
Formula
C17H20ClFN4OS
Canonical SMILES
CC1=CC2=C(N=C(N=C2S1)N3CCNCC3)C4=CC=CC=C4F.O.Cl
InChI
1S/C17H17FN4S.ClH.H2O/c1-11-10-13-15(12-4-2-3-5-14(12)18)20-17(21-16(13)23-11)22-8-6-19-7-9-22;;/h2-5,10,19H,6-9H2,1H3;1H;1H2
InChIKey
SAURKKOJWIFYSR-UHFFFAOYSA-N
CAS Number
CAS 135991-48-9
PubChem Compound ID
6918194
PubChem Substance ID
12014606, 14756031, 17194731, 43529584, 77052129, 114787587, 134339252, 163642388, 198962841, 226950171, 241033109
Target and Pathway
Target(s) 5-HT 3 receptor Target Info Modulator [1572591]
References
Ref 536224Emerging drugs for irritable bowel syndrome. Expert Opin Emerg Drugs. 2006 May;11(2):293-313.
Ref 1572591Interpreting expression profiles of cancers by genome-wide survey of breadth of expression in normal tissues. Genomics 2005 Aug;86(2):127-41.

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