Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04FKX
|
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| Former ID |
DNCL002410
|
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| Drug Name |
D-3263
|
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| Drug Type |
Small molecular drug
|
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| Indication | Solid tumours [ICD9: 140-199, 210-229; ICD10:C00-D48] | Phase 1 | [1] | ||
| Company |
Dendreon
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C12H16BF4N5O2
|
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| Canonical SMILES |
[B-](F)(F)(F)F.CN(C)C(=[N+](C)C)ON1C(=O)C2=CC=CC=C2N=N1
|
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| InChI |
1S/C12H16N5O2.BF4/c1-15(2)12(16(3)4)19-17-11(18)9-7-5-6-8-10(9)13-14-17;2-1(3,4)5/h5-8H,1-4H3;/q+1;-1
|
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| InChIKey |
FOBCPCIJLQTYBT-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
15928782, 23130537, 24863207, 42062750, 57375470, 57649719, 75924159, 87245350, 91694285, 117656930, 118318595, 125339590, 126652203, 126664142, 136990598, 143491797, 152049580, 152243761, 160870982, 162186783, 162246152, 162278347, 163303114, 163782493, 163802232, 174526928, 184581691, 204362693, 223391286, 223656931, 223812404, 226840397, 252150885, 252265924, 252355404, 252430570, 252810060
|
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| Target and Pathway | |||||
| Target(s) | TRPM8 protein | Target Info | Modulator | [2] | |
| KEGG Pathway | Inflammatory mediator regulation of TRP channels | ||||
| Reactome | TRP channels | ||||
| References | |||||
| REF 1 | ClinicalTrials.gov (NCT00839631) Dose Escalation Study of EC D-3263 HCl in Advanced Solid Tumors. U.S. National Institutes of Health. | ||||
| REF 2 | Best of the 2009 AUA Annual Meeting: Highlights from the 2009 Annual Meeting of the American Urological Association, April 25-30, 2009, Chicago, IL. Rev Urol. 2009 Spring; 11(2): 82-107. | ||||
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