Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04GDI
|
||||
| Former ID |
DIB003932
|
||||
| Drug Name |
NP93-31
|
||||
| Synonyms |
NP93-31; Neup-93-31; NMDA NR2B antagonists (depression/neuropathic pain/subarachnoid hemorrhage/traumatic brain injury); NMDA NR2B antagonists (depression/neuropathic pain/subarachnoid hemorrhage/TBI), NeurOp/ Bristol-Myers Squibb/Stallion; NMDA NR2B antagonists (depression/neuropathic pain/subarachnoid hemorrhage/traumatic brain injury), NeurOp/ Bristol-Myers Squibb/Stallion
|
||||
| Indication | Brain injury [ICD10:S09.90] | Investigative | [1] | ||
| Company |
NeurOp Corp
|
||||
| Target and Pathway | |||||
| Target(s) | Glutamate [NMDA] receptor subunit epsilon 2 | Target Info | Antagonist | [1] | |
| KEGG Pathway | Ras signaling pathway | ||||
| Rap1 signaling pathway | |||||
| cAMP signaling pathway | |||||
| Neuroactive ligand-receptor interaction | |||||
| Circadian entrainment | |||||
| Long-term potentiation | |||||
| Glutamatergic synapse | |||||
| Dopaminergic synapse | |||||
| Alzheimer's disease | |||||
| Amyotrophic lateral sclerosis (ALS) | |||||
| Huntington's disease | |||||
| Cocaine addiction | |||||
| Amphetamine addiction | |||||
| Nicotine addiction | |||||
| Alcoholism | |||||
| Systemic lupus erythematosus | |||||
| PANTHER Pathway | Huntington disease | ||||
| Ionotropic glutamate receptor pathway | |||||
| Metabotropic glutamate receptor group III pathway | |||||
| Metabotropic glutamate receptor group I pathway | |||||
| Muscarinic acetylcholine receptor 1 and 3 signaling pathway | |||||
| Pathway Interaction Database | ErbB4 signaling events | ||||
| Reelin signaling pathway | |||||
| Reactome | EPHB-mediated forward signaling | ||||
| Unblocking of NMDA receptor, glutamate binding and activation | |||||
| CREB phosphorylation through the activation of CaMKII | |||||
| Ras activation uopn Ca2+ infux through NMDA receptor | |||||
| RAF/MAP kinase cascade | |||||
| WikiPathways | Hypothetical Network for Drug Addiction | ||||
| Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell | |||||
| BDNF signaling pathway | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 457). | ||||
If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.