Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04HEZ
|
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| Former ID |
DIB018214
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| Drug Name |
[3H](R)-alpha-methylhistamine
|
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| Synonyms |
(R)-[3H]alpha-methylhistamine; [3H]-R-alpha-Methylhistamine
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| Drug Type |
Small molecular drug
|
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| Indication | Discovery agent | Investigative | [1] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C6H11N3
|
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| InChI |
InChI=1S/C6H11N3/c1-5(7)2-6-3-8-4-9-6/h3-5H,2,7H2,1H3,(H,8,9)/t5-/m1/s1
|
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| InChIKey |
XNQIOISZPFVUFG-RXMQYKEDSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID |
7978667, 11113570, 15146561, 16093057, 26751775, 46232384, 47434820, 47515539, 47885613, 48105152, 48179687, 48334726, 48404445, 49846718, 50065157, 50075028, 50104462, 57348301, 76714569, 90340819, 103173299, 103942877, 113435493, 117393350, 124749862, 129714812, 132626135, 134338589, 134346127, 135112540, 135650415, 135651165, 139603316, 140261834, 163425851, 164229681, 179151084, 184607645, 224300217, 226453626, 230109526, 244113949
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| Target and Pathway | |||||
| Target(s) | Histamine H4 receptor | Target Info | Agonist | [2] | |
| Histamine H3 receptor | Target Info | Agonist | [2] | ||
| KEGG Pathway | Neuroactive ligand-receptor interactionhsa04080:Neuroactive ligand-receptor interaction | ||||
| Reactome | Histamine receptors | ||||
| G alpha (i) signalling eventsR-HSA-390650:Histamine receptors | |||||
| G alpha (i) signalling events | |||||
| WikiPathways | GPCR ligand binding | ||||
| GPCR downstream signaling | |||||
| GPCRs, OtherWP727:Monoamine Transport | |||||
| GPCRs, Class A Rhodopsin-like | |||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1237). | ||||
| REF 2 | Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol Pharmacol. 2001 Mar;59(3):420-6. | ||||
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