Drug Information
Drug General Information | |||||
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Drug ID |
D04HYP
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Former ID |
DNC000133
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Drug Name |
ABT-594
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Drug Type |
Small molecular drug
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Structure |
Download2D MOL |
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Formula |
C9H11ClN2O
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InChI |
InChI=1S/C9H11ClN2O/c10-9-2-1-8(5-12-9)13-6-7-3-4-11-7/h1-2,5,7,11H,3-4,6H2/t7-/m1/s1
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InChIKey |
MKTAGSRKQIGEBH-SSDOTTSWSA-N
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CAS Number |
CAS 198283-73-7
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Neuronal acetylcholine receptor protein, beta-2 chain | Target Info | Agonist | [534971] | |
Neuronal acetylcholine receptor protein, alpha-4 chain | Target Info | Agonist | [534971] | ||
Nicotinic acetylcholine receptor | Target Info | Agonist | [534971], [538100] | ||
Reactome | Highly sodium permeable acetylcholine nicotinic receptors | ||||
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors | |||||
Highly calcium permeable nicotinic acetylcholine receptorsR-HSA-629587:Highly sodium permeable acetylcholine nicotinic receptors | |||||
Highly calcium permeable nicotinic acetylcholine receptors | |||||
References | |||||
Ref 540604 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3989). | ||||
Ref 546684 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009632) | ||||
Ref 534971 | The nicotinic acetylcholine receptor agonist ABT-594 increases FGF-2 expression in various rat brain regions. Neuroreport. 1999 Dec 16;10(18):3909-13. | ||||
Ref 538100 | ABT-594 [(R)-5-(2-azetidinylmethoxy)-2-chloropyridine]: a novel, orally effective antinociceptive agent acting via neuronal nicotinic acetylcholine receptors: II. In vivo characterization. J Pharmacol Exp Ther. 1998 May;285(2):787-94. |
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