Drug General Information
Drug ID
D04HZA
Former ID
DNC006008
Drug Name
2-(2-bromo-2-naphthamido)benzoic acid
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527807]
Structure
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2D MOL

3D MOL

Formula
C18H12BrNO3
Canonical SMILES
C1=CC=C(C(=C1)C(=O)O)NC(=O)C2=CC3=C(C=C2)C=C(C=C3)Br
InChI
1S/C18H12BrNO3/c19-14-8-7-11-9-13(6-5-12(11)10-14)17(21)20-16-4-2-1-3-15(16)18(22)23/h1-10H,(H,20,21)(H,22,23)
InChIKey
KNVPXLPBRSRJCV-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Dihydroorotate dehydrogenase, mitochondrial Target Info Inhibitor [527807]
KEGG Pathway Pyrimidine metabolism
Metabolic pathways
PathWhiz Pathway Pyrimidine Metabolism
Reactome Pyrimidine biosynthesis
WikiPathways Metabolism of nucleotides
References
Ref 527807Bioorg Med Chem Lett. 2006 Jan 1;16(1):88-92. Epub 2005 Oct 19.The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.
Ref 527807Bioorg Med Chem Lett. 2006 Jan 1;16(1):88-92. Epub 2005 Oct 19.The first de novo designed inhibitors of Plasmodium falciparum dihydroorotate dehydrogenase.

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