Drug General Information
Drug ID	D04IDW
Former ID	DIB007888
Drug Name	SNS-314 prodrugs
Synonyms	SNS-314 prodrugs (cancer); SNS-314 prodrugs (cancer), Sunesis
Indication	Cancer [ICD9: 140-229; ICD10:C00-C96]		Investigative	[543524]
Company	Sunesis Pharmaceuticals Inc
Structure		Download 2D MOL 3D MOL
Canonical SMILES	O=P(O)(OCn1cc(s/c/1=N/C(=O)Nc1cc(ccc1)Cl)CCNc1ncnc2ccsc<br />12)O
Target and Pathway
Target(s)	Aurora protein kinase	Target Info	Inhibitor	[543524]
KEGG Pathway	Oocyte meiosis
Reactome	APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1
	Separation of Sister Chromatids
	Resolution of Sister Chromatid Cohesion
	RHO GTPases Activate Formins
WikiPathways	EGF/EGFR Signaling Pathway
	JAK/STAT
	Gastric Cancer Network 1
	Integrated Breast Cancer Pathway
	APC/C-mediated degradation of cell cycle proteins
References
Ref 543524	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936).
Ref 543524	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 1936).

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