Drug Information

Drug General Information
Drug ID
D04JDQ
Former ID
DNC005426
Drug Name
6-Furan-2-yl-9-phenethyl-9H-purin-2-ylamine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527503]
Structure
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2D MOL

3D MOL
Formula
C17H15N5O
Canonical SMILES
C1=CC=C(C=C1)CCN2C=NC3=C(N=C(N=C32)N)C4=CC=CO4
InChI
1S/C17H15N5O/c18-17-20-14(13-7-4-10-23-13)15-16(21-17)22(11-19-15)9-8-12-5-2-1-3-6-12/h1-7,10-11H,8-9H2,(H2,18,20,21)
InChIKey
LOCNLYLIABVQFH-UHFFFAOYSA-N
PubChem Compound ID
44401799
Target and Pathway
Target(s) Adenosine A2a receptor Target Info Inhibitor [527503]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Parkinson's disease
Alcoholism
Pathway Interaction Database HIF-2-alpha transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome NGF-independant TRKA activation
Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
Monoamine Transport
GPCRs, Class A Rhodopsin-like
NGF signalling via TRKA from the plasma membrane
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 527503Bioorg Med Chem Lett. 2005 Apr 15;15(8):2119-22.6-(2-Furanyl)-9H-purin-2-amine derivatives as A2A adenosine antagonists.
Ref 527503Bioorg Med Chem Lett. 2005 Apr 15;15(8):2119-22.6-(2-Furanyl)-9H-purin-2-amine derivatives as A2A adenosine antagonists.

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