Drug Information

Drug General Information
Drug ID
D04JJL
Former ID
DNC011515
Drug Name
N,N'-Bis-(4-ethyl-phenyl)-guanidine
Drug Type
Small molecular drug
Indication Discovery agent Investigative [534685]
Structure
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2D MOL

3D MOL
Formula
C17H21N3
Canonical SMILES
CCC1=CC=C(C=C1)NC(=NC2=CC=C(C=C2)CC)N
InChI
1S/C17H21N3/c1-3-13-5-9-15(10-6-13)19-17(18)20-16-11-7-14(4-2)8-12-16/h5-12H,3-4H2,1-2H3,(H3,18,19,20)
InChIKey
DXGARAMIKHFTJV-UHFFFAOYSA-N
PubChem Compound ID
14771671
Target and Pathway
Target(s) Glutamate [NMDA] receptor subunit epsilon 1 Target Info Inhibitor [534685]
Glutamate [NMDA] receptor subunit epsilon 2 Target Info Inhibitor [534685]
NMDA receptor subunit NR1 Target Info Inhibitor [534685]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Dopaminergic synapse
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Cocaine addiction
Amphetamine addiction
Nicotine addiction
Alcoholism
Systemic lupus erythematosushsa04014:Ras signaling pathway
Huntington's disease
PANTHER Pathway Huntington disease
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database Reelin signaling pathwayerbb4_pathway:ErbB4 signaling events
Reelin signaling pathway
Reactome Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
RAF/MAP kinase cascade
WikiPathways Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
BDNF signaling pathwayWP706:SIDS Susceptibility Pathways
Spinal Cord Injury
BDNF signaling pathway
Alzheimers Disease
References
Ref 534685J Med Chem. 1998 Aug 13;41(17):3298-302.Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents.
Ref 534685J Med Chem. 1998 Aug 13;41(17):3298-302.Synthesis and pharmacological evaluation of N,N'-diarylguanidines as potent sodium channel blockers and anticonvulsant agents.

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