Drug Information

Drug General Information
Drug ID
D04JZH
Former ID
DIB001125
Drug Name
PF-01247324
Synonyms
PF-01247324; Nav1.8 blockers (pain); Nav1.8 blockers (pain), Pfizer; Voltage-gated sodium channel 1.8 blockers (pain), Pfizer
Drug Type
Small molecular drug
Indication Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89] Phase 1 [543182]
Company
Pfizer Inc
Structure
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2D MOL

3D MOL
Formula
C13H10Cl3N3O
InChIKey
HPIUHDCRVYDAEJ-UHFFFAOYSA-N
PubChem Compound ID
11659955
PubChem Substance ID
16763601, 23760470, 77348415, 140420821, 162700707, 204384157, 229477002, 248937995, 252166723
Target and Pathway
Target(s) Voltage-gated sodium channel subunit alpha Nav1.8 Target Info Blocker [544467]
Reactome Interaction between L1 and Ankyrins
References
Ref 543182(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8521).
Ref 544467Oral Administration of PF-01247324, a Subtype-Selective Nav1.8 Blocker, Reverses Cerebellar Deficits in a Mouse Model of Multiple Sclerosis. PLoS One. 2015; 10(3): e0119067.

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