Drug Information
Drug General Information | |||||
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Drug ID |
D04LOE
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Former ID |
DIB019386
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Drug Name |
compound 26
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Synonyms |
1,2,4-oxadiazole_based compound 26; Merck SIP agonist
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Drug Type |
Small molecular drug
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Formula |
C23H25N3O3
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InChI |
InChI=1S/C23H25N3O3/c1-15(2)11-16-3-9-19(10-4-16)22-24-21(25-29-22)18-7-5-17(6-8-18)12-26-13-20(14-26)23(27)28/h3-10,15,20H,11-14H2,1-2H3,(H,27,28)
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InChIKey |
SHQNRSGKLNMHOS-UHFFFAOYSA-N
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PubChem Compound ID | |||||
PubChem Substance ID | |||||
Target and Pathway | |||||
Target(s) | Sphingosine 1-phosphate receptor 1 | Target Info | Agonist | [527767] | |
S1P4 receptor | Target Info | Agonist | [527767] | ||
Sphingosine-1-phosphate receptor-3 | Target Info | Agonist | [527767] | ||
Sphingosine 1-phosphate receptor 5 | Target Info | Agonist | [527767] | ||
References | |||||
Ref 527767 | Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3. J Med Chem. 2005 Oct 6;48(20):6169-73. | ||||
Ref 539946 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2929). |
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