Drug General Information
Drug ID
D04LOE
Former ID
DIB019386
Drug Name
compound 26
Synonyms
1,2,4-oxadiazole_based compound 26; Merck SIP agonist
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527767], [539946]
Formula
C23H25N3O3
InChI
InChI=1S/C23H25N3O3/c1-15(2)11-16-3-9-19(10-4-16)22-24-21(25-29-22)18-7-5-17(6-8-18)12-26-13-20(14-26)23(27)28/h3-10,15,20H,11-14H2,1-2H3,(H,27,28)
InChIKey
SHQNRSGKLNMHOS-UHFFFAOYSA-N
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Sphingosine 1-phosphate receptor 1 Target Info Agonist [527767]
S1P4 receptor Target Info Agonist [527767]
Sphingosine-1-phosphate receptor-3 Target Info Agonist [527767]
Sphingosine 1-phosphate receptor 5 Target Info Agonist [527767]
KEGG Pathway FoxO signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interactionhsa04071:Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
NetPath Pathway IL4 Signaling Pathway
TGF_beta_Receptor Signaling Pathway
IL2 Signaling Pathway
Pathway Interaction Database Fc-epsilon receptor I signaling in mast cells
S1P3 pathway
S1P1 pathway
Sphingosine 1-phosphate (S1P) pathway
PDGFR-beta signaling pathways1p_s1p3_pathway:S1P3 pathway
Sphingosine 1-phosphate (S1P) pathways1p_s1p4_pathway:S1P4 pathway
S1P5 pathway
Reactome G alpha (i) signalling events
Lysosphingolipid and LPA receptorsR-HSA-418594:G alpha (i) signalling events
Lysosphingolipid and LPA receptors
WikiPathways Signal Transduction of S1P Receptor
Small Ligand GPCRs
GPCR ligand binding
GPCR downstream signaling
GPCRs, OtherWP26:Signal Transduction of S1P Receptor
GPCR downstream signalingWP26:Signal Transduction of S1P Receptor
References
Ref 527767Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3. J Med Chem. 2005 Oct 6;48(20):6169-73.
Ref 539946(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2929).
Ref 527767Discovery of potent 3,5-diphenyl-1,2,4-oxadiazole sphingosine-1-phosphate-1 (S1P1) receptor agonists with exceptional selectivity against S1P2 and S1P3. J Med Chem. 2005 Oct 6;48(20):6169-73.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.