Drug General Information
Drug ID	D04MOF
Former ID	DCL000882
Drug Name	Milveterol+Fluticasone
Drug Type	Small molecular drug
Indication	Asthma; Chronic obstructive pulmonary disease [ICD9: 490-492, 493, 494-496; ICD10:J40-J44, J47, J45]		Discontinued in Phase 2	[550969]
Company	GlaxoSmithKline
Structure		Download 2D MOL 3D MOL
Formula	C22H27F3O4S
PubChem Compound ID	62924
Target and Pathway
Target(s)	Beta-2 adrenergic receptor	Target Info	Agonist	[537130]
KEGG Pathway	Calcium signaling pathway
	cGMP-PKG signaling pathway
	cAMP signaling pathway
	Neuroactive ligand-receptor interaction
	Endocytosis
	Adrenergic signaling in cardiomyocytes
	Salivary secretion
NetPath Pathway	TCR Signaling Pathway
PANTHER Pathway	Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
	Beta2 adrenergic receptor signaling pathway
Pathway Interaction Database	Arf6 trafficking events
	Arf6 signaling events
Reactome	Adrenoceptors
	G alpha (s) signalling events
WikiPathways	Monoamine GPCRs
	Calcium Regulation in the Cardiac Cell
	GPCRs, Class A Rhodopsin-like
	Vitamin D Receptor Pathway
	GPCR ligand binding
	GPCR downstream signaling
	GPCRs, Other
References
Ref 550969	Clinical pipeline report, company report or official report of GlaxoSmithKline.
Ref 537130	Emerging drugs in chronic obstructive pulmonary disease. Expert Opin Emerg Drugs. 2009 Mar;14(1):181-94.

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