Drug Information

Drug General Information
Drug ID
D04NPP
Former ID
DNCL001638
Drug Name
SLX-2101
Indication Erectile dysfunction; Hypertension; Raynaud's disease [ICD9: 302.72, 607.84, 401, 443; ICD10:F52.2, N48.4, I10-I16, I73.0] Discontinued in Phase 2 [548157]
Company
Kadmon Pharmaceuticals; Nano Terra
Target and Pathway
Target(s) CGMP-specific 3',5'-cyclic phosphodiesterase Target Info Inhibitor [529481]
KEGG Pathway Purine metabolism
cGMP-PKG signaling pathway
NetPath Pathway TGF_beta_Receptor Signaling Pathway
Reactome cGMP effects
References
Ref 548157Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800022583)
Ref 529481Novel phosphodiesterase-5 (PDE5) inhibitors in the alleviation of erectile dysfunction due to diabetes and ageing-induced oxidative stress. Expert Opin Investig Drugs. 2008 Jun;17(6):855-64.

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