Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D04PMM
|
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| Former ID |
DCL000455
|
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| Drug Name |
AZD1386
|
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| Drug Type |
Small molecular drug
|
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| Indication | Esophagus sensitivity; Gastroesophageal reflux disease [ICD9: 530, 140-229; ICD10:K20-K22, K21] | Discontinued in Phase 2 | [1], [2] | ||
| Therapeutic Class |
Analgesics
|
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| Company |
AstraZeneca
|
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| Structure |
|
Download2D MOL |
|||
| Formula |
C19H13ClF3N3O3
|
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| InChI |
InChI=1S/C19H13ClF3N3O3/c1-9-5-12(20)7-13-14(9)26(16(28)18(13)15(27)24-17(29)25-18)8-10-3-2-4-11(6-10)19(21,22)23/h2-7H,8H2,1H3,(H2,24,25,27,29)
|
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| InChIKey |
DXDVSYALLVVBOV-UHFFFAOYSA-N
|
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| PubChem Compound ID | |||||
| PubChem Substance ID | |||||
| Target and Pathway | |||||
| Target(s) | Vanilloid receptor 1 | Target Info | Blocker | [3] | |
| KEGG Pathway | Neuroactive ligand-receptor interaction | ||||
| Inflammatory mediator regulation of TRP channels | |||||
| NetPath Pathway | IL2 Signaling Pathway | ||||
| Pathway Interaction Database | Trk receptor signaling mediated by the MAPK pathway | ||||
| Trk receptor signaling mediated by PI3K and PLC-gamma | |||||
| Reactome | TRP channels | ||||
| References | |||||
| REF 1 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7820). | ||||
| REF 2 | Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027672) | ||||
| REF 3 | Clinical pipeline report, company report or official report of AstraZeneca (2009). | ||||
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