Drug Information

Drug General Information
Drug ID
D04QSJ
Former ID
DNC001188
Drug Name
R0-93877
Drug Type
Small molecular drug
Indication Constipation [ICD9: 564; ICD10:K59.0] Approved [546610], [551871]
Structure
Download
2D MOL

3D MOL
Formula
C18H26ClN3O3
Canonical SMILES
COCCCN1CCC(CC1)NC(=O)C2=CC(=C(C3=C2OCC3)N)Cl
InChI
1S/C18H26ClN3O3/c1-24-9-2-6-22-7-3-12(4-8-22)21-18(23)14-11-15(19)16(20)13-5-10-25-17(13)14/h11-12H,2-10,20H2,1H3,(H,21,23)
InChIKey
ZPMNHBXQOOVQJL-UHFFFAOYSA-N
CAS Number
CAS 86639-52-3
PubChem Compound ID
3052762
PubChem Substance ID
10056110, 14803834, 36118680, 50329889, 57353981, 85209596, 96025885, 103341576, 104015490, 111619007, 124772073, 126522466, 126666797, 126731460, 129936276, 134340386, 135131495, 135650861, 135697691, 136367812, 137009981, 142510835, 143497674, 152090515, 152159696, 152234885, 162009741, 162011596, 162205091, 164764612, 170466188, 170502890, 174006285, 174528011, 175438062, 179150084, 185997006, 188899543, 196408592, 198942073, 198993142, 210275056, 210280694, 223379010, 223662148, 226407081, 249734221, 251883665, 251971243, 252151346
Target and Pathway
Target(s) 5-hydroxytryptamine 4 receptor Target Info Agonist [535146]
KEGG Pathway Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT4 type receptor mediated signaling pathway
PathWhiz Pathway Excitatory Neural Signalling Through 5-HTR 4 and Serotonin
Reactome Serotonin receptors
G alpha (s) signalling events
WikiPathways Serotonin Receptor 4/6/7 and NR3C Signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 546610Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800009175)
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
Ref 535146Irritable bowel syndrome: new agents targeting serotonin receptor subtypes. Drugs. 2001;61(3):317-32.

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