| Drug General Information |
| Drug ID |
D04UDT
|
| Former ID |
DNC014337
|
| Drug Name |
MEBUDIPINE
|
| Drug Type |
Small molecular drug
|
| Indication |
Discovery agent
|
Investigative |
[1]
|
|---|
| Structure |
|
Download
2D MOL
3D MOL
|
| Formula |
C20H24N2O6
|
| Canonical SMILES |
CC1=C(C(C(=C(N1)C)C(=O)OC(C)(C)C)C2=CC(=CC=C2)[N+](=O)[<br />O-])C(=O)OC
|
| InChI |
1S/C20H24N2O6/c1-11-15(18(23)27-6)17(13-8-7-9-14(10-13)22(25)26)16(12(2)21-11)19(24)28-20(3,4)5/h7-10,17,21H,1-6H3
|
| InChIKey |
YXPRKGBMFPQBDH-UHFFFAOYSA-N
|
| PubChem Compound ID |
|
| Target and Pathway |
| Target(s) |
Voltage-dependent L-type calcium channel subunit alpha-1C |
Target Info |
Inhibitor |
[1]
|
|---|
| Voltage-dependent L-type calcium channel alpha-1D subunit |
Target Info |
Inhibitor |
[1]
|
|
KEGG Pathway
|
MAPK signaling pathway
|
|
Calcium signaling pathway
|
|
cGMP-PKG signaling pathway
|
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cAMP signaling pathway
|
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Cardiac muscle contraction
|
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Adrenergic signaling in cardiomyocytes
|
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Vascular smooth muscle contraction
|
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Circadian entrainment
|
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Long-term potentiation
|
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Retrograde endocannabinoid signaling
|
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Glutamatergic synapse
|
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Cholinergic synapse
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Serotonergic synapse
|
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GABAergic synapse
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Dopaminergic synapse
|
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Insulin secretion
|
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GnRH signaling pathway
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Oxytocin signaling pathway
|
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Type II diabetes mellitus
|
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Alzheimer's disease
|
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Amphetamine addiction
|
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Hypertrophic cardiomyopathy (HCM)
|
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Arrhythmogenic right ventricular cardiomyopathy (ARVC)
|
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Dilated cardiomyopathyhsa04010:MAPK signaling pathway
|
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Carbohydrate digestion and absorption
|
|
Dilated cardiomyopathy
|
|
NetPath Pathway
|
IL2 Signaling Pathway
|
|
PANTHER Pathway
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Alzheimer disease-amyloid secretase pathway
|
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Nicotinic acetylcholine receptor signaling pathway
|
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5HT2 type receptor mediated signaling pathway
|
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Beta1 adrenergic receptor signaling pathway
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Beta2 adrenergic receptor signaling pathway
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Oxytocin receptor mediated signaling pathway
|
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Nicotine pharmacodynamics pathwayP00003:Alzheimer disease-amyloid secretase pathway
|
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PathWhiz Pathway
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Muscle/Heart Contraction
|
|
Reactome
|
Adrenaline,noradrenaline inhibits insulin secretion
|
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NCAM1 interactions
|
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Regulation of insulin secretionR-HSA-400042:Adrenaline,noradrenaline inhibits insulin secretion
|
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Regulation of insulin secretion
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WikiPathways
|
Calcium Regulation in the Cardiac Cell
|
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Arrhythmogenic Right Ventricular Cardiomyopathy
|
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Alzheimers Disease
|
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NCAM signaling for neurite out-growth
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Integration of energy metabolism
|
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Nicotine Activity on Chromaffin CellsWP536:Calcium Regulation in the Cardiac Cell
|
| References |
| REF 1 | Bioorg Med Chem. 2010 May 1;18(9):3147-58. Epub 2010 Mar 19.Antagonism of 4-substituted 1,4-dihydropyridine-3,5-dicarboxylates toward voltage-dependent L-type Ca2+ channels Ca V 1.3 and Ca V 1.2. |
|---|
