Drug Information

Drug General Information
Drug ID
D05BYA
Former ID
DCL001115
Drug Name
NVP-AUY922
Synonyms
VER-52296; VER-52296/NVP-AUY922; AUY922, VER-52296, NVP-AUY922
Drug Type
Small molecular drug
Indication Cancer [ICD9: 140-229; ICD10:C00-C96] Phase 2 [548611]
Therapeutic Class
Anticancer Agents
Company
Vernalis; Novartis
Structure
Download
2D MOL

3D MOL
Formula
C26H31N3O5
Canonical SMILES
CCNC(=O)C1=C(C(=C2C=C(C(=CC2=O)O)C(C)C)ON1)C3=CC=C(C=C3<br />)CN4CCOCC4
InChI
1S/C26H31N3O5/c1-4-27-26(32)24-23(18-7-5-17(6-8-18)15-29-9-11-33-12-10-29)25(34-28-24)20-13-19(16(2)3)21(30)14-22(20)31/h5-8,13-14,16,28,30H,4,9-12,15H2,1-3H3,(H,27,32)/b25-20-
InChIKey
SWDZPNJZKUGIIH-QQTULTPQSA-N
PubChem Compound ID
10096043
PubChem Substance ID
15083415, 39155921, 46484819, 49689000, 76608378, 99436965, 103556527, 124756976, 125163781, 126581936, 126738735, 131480668, 135727472, 136367275, 136367858, 136920354, 137245317, 138971951, 140671853, 143499493, 144116295, 152105921, 152237713, 152258028, 152258131, 152344085, 160646970, 162011585, 162037415, 162202735, 163642590, 164044840, 164193951, 174530564, 177748703, 185975634, 188899501, 198974570, 223401065, 223448353, 223680473, 228770821, 249814513, 251963184, 251971001, 252160237, 252215929
Target and Pathway
Target(s) Heat shock protein HSP90 Target Info Inhibitor [536886]
References
Ref 548611Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800027019)
Ref 536886Recent advances in Hsp90 inhibitors as antitumor agents. Anticancer Agents Med Chem. 2008 Oct;8(7):761-82.

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