TTD | Drug: D05DYX

Drug General Information
Drug ID	D05DYX
Former ID	DIB021261
Drug Name	ZM 253270
Synonyms	ZM-253270; ZM253270
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[541096]
Structure		Download 2D MOL 3D MOL
Formula	C22H26ClN7O3
InChI	InChI=1S/C22H26ClN7O3/c1-13(2)30-12-17-18(21(30)32)25-22(26-19(17)24-16-6-4-15(23)5-7-16)29-10-8-28(9-11-29)20(31)14(3)27-33/h4-7,13,33H,8-12H2,1-3H3,(H,24,25,26)/b27-14+
InChIKey	OYOSXTKSOATNNB-MZJWZYIUSA-N
PubChem Compound ID	9847605
PubChem Substance ID	14809643, 24144391, 44945671, 47359856, 48404438, 76433752, 137058892
Target and Pathway
Target(s)	NK-2 receptor	Target Info	Antagonist	[533637]
KEGG Pathway	Calcium signaling pathway
KEGG Pathway	Neuroactive ligand-receptor interaction
Reactome	G alpha (q) signalling events
WikiPathways	Gastrin-CREB signalling pathway via PKC and MAPK
	Peptide GPCRs
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 541096	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 5771).
Ref 533637	Pharmacological characterization of a new class of nonpeptide neurokinin A antagonists that demonstrate species selectivity. J Pharmacol Exp Ther. 1995 Sep;274(3):1216-21.

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Drug Information