Drug Information

Drug General Information
Drug ID
D05FYR
Former ID
DIB020009
Drug Name
hK2p01 derivative KLK2 inhibitor
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528079]
Structure
Download
2D MOL
Formula
C59H82N16O11
InChI
InChI=1S/C59H82N16O11/c1-32(2)49(75-54(82)43(22-13-14-24-60)71-56(84)45(26-36-16-7-6-8-17-36)72-53(81)44(70-50(78)33(3)61)23-15-25-64-59(62)63)58(86)74-47(28-38-30-66-42-21-12-10-19-40(38)42)57(85)73-46(27-37-29-65-41-20-11-9-18-39(37)41)55(83)69-35(5)52(80)68-34(4)51(79)67-31-48(76)77/h6-12,16-21,29-30,32-35,43-47,49,65-66H,13-15,22-28,31,60-61H2,1-5H3,(H,67,79)(H,68,80)(H,69,83)(H,70,78)(H,71,84)(H,72,81)(H,73,85)(H,74,86)(H,75,82)(H,76,77)(H4,62,63,64)/t33-,34-,35-,43-,44-,45-,46-,47-,49-/m0/s1
InChIKey
BVRWWHKWGPOKPN-NXOPMQQOSA-N
PubChem Compound ID
11700955
PubChem Substance ID
16805399, 77858585, 163317687, 163345187, 252166872
Target and Pathway
Target(s) Tissue kallikrein Target Info Inhibitor [528079]
KEGG Pathway Endocrine and other factor-regulated calcium reabsorption
NetPath Pathway IL2 Signaling Pathway
Pathway Interaction Database Coregulation of Androgen receptor activity
Regulation of Androgen receptor activity
Reactome Activation of Matrix Metalloproteinases
Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
WikiPathways Prostate Cancer
References
Ref 528079Novel peptide inhibitors of human kallikrein 2. J Biol Chem. 2006 May 5;281(18):12555-60. Epub 2006 Mar 9.
Ref 528079Novel peptide inhibitors of human kallikrein 2. J Biol Chem. 2006 May 5;281(18):12555-60. Epub 2006 Mar 9.

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