Drug General Information
Drug ID	D05GKD
Former ID	DAP000140
Drug Name	Tramadol
Synonyms	Conzip; Ryzolt; Tramadol Hydrochloride; Ultram Er; Rybix Odt; Ultram; Ultram
Drug Type	Small molecular drug
Indication	Pain [ICD9: 338, 356.0, 356.8,780; ICD10:G64, G90.0, R52, G89]		Approved	[537244], [543040]
Therapeutic Class	Analgesics
Company	Chemie Grunenthal of Stolberg-am-Rhein
Structure		Download 2D MOL 3D MOL
Formula	C16H25NO2
InChIKey	TVYLLZQTGLZFBW-UHFFFAOYSA-N
CAS Number	CAS 27203-92-5
PubChem Compound ID	5523
PubChem Substance ID	5658598, 8153398, 15221636, 29224565, 49958171, 49958172, 49958173, 50837838, 85209685, 103113054, 104309473, 117617520, 123083206, 125679912, 126682485, 129321889, 134995846, 135060961, 137010486, 142192184, 162831124, 164174929, 164765703, 164765706, 179225203, 184526607, 184596120, 216106831, 223656715, 223766038, 226439878, 241058775, 244533735, 249923528, 252166498
SuperDrug ATC ID	N02AX02
SuperDrug CAS ID	cas=027203925
Target and Pathway
Target(s)	5-hydroxytryptamine 2C receptor	Target Info	Modulator	[527050]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (q) signalling events
WikiPathways	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signaling
References
Ref 537244	Local effect of tramadol on formalin evoked flinching behavior in rats. Rev Bras Anestesiol. 2008 Jul-Aug;58(4):375-9, 371-5.
Ref 543040	(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8286).
Ref 527050	The inhibitory effects of tramadol on 5-hydroxytryptamine type 2C receptors expressed in Xenopus oocytes. Anesth Analg. 2004 May;98(5):1401-6, table of contents.

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