Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05HUX
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| Former ID |
DNC000776
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| Drug Name |
ICRF-154
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| Drug Type |
Small molecular drug
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| Indication | Discovery agent | Investigative | [535604] | ||
| Structure |
|
Download2D MOL |
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| Formula |
C10H14N4O4
|
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| Canonical SMILES |
C1C(=O)NC(=O)CN1CCN2CC(=O)NC(=O)C2
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| InChI |
1S/C10H14N4O4/c15-7-3-13(4-8(16)11-7)1-2-14-5-9(17)12-10(18)6-14/h1-6H2,(H,11,15,16)(H,12,17,18)
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| InChIKey |
GBLIGNUYGOFIKS-UHFFFAOYSA-N
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| CAS Number |
CAS 1506-47-4
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| PubChem Compound ID | |||||
| PubChem Substance ID |
420632, 4411092, 8195358, 14971358, 43128836, 57318825, 76442978, 81093067, 90490413, 92714422, 103134857, 104353639, 105193276, 117600768, 117930438, 124896349, 125703789, 126629560, 127929939, 131299819, 135030053, 137066001, 162795043, 164235703, 169681713, 184548213, 198936128, 224879449, 227016967, 241034074, 242574218, 252558454
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| Target and Pathway | |||||
| Target(s) | DNA topoisomerase II | Target Info | Inhibitor | [535604] | |
| References | |||||
| Ref 535604 | The catalytic DNA topoisomerase II inhibitor ICRF-193 and all-trans retinoic acid cooperatively induce granulocytic differentiation of acute promyelocytic leukemia cells: candidate drugs for chemo-differentiation therapy against acute promyelocytic leukemia. Exp Hematol. 2002 Nov;30(11):1273-82. | ||||
| Ref 535604 | The catalytic DNA topoisomerase II inhibitor ICRF-193 and all-trans retinoic acid cooperatively induce granulocytic differentiation of acute promyelocytic leukemia cells: candidate drugs for chemo-differentiation therapy against acute promyelocytic leukemia. Exp Hematol. 2002 Nov;30(11):1273-82. | ||||
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