Drug General Information
Drug ID	D05JIO
Former ID	DNC008388
Drug Name	(2S)-1-(6-fluoro-1H-indazol-1-yl)propan-2-amine
Drug Type	Small molecular drug
Indication	Discovery agent		Investigative	[529168]
Structure		Download 2D MOL 3D MOL
Formula	C10H12FN3
Canonical SMILES	CC(CN1C2=C(C=CC(=C2)F)C=N1)N
InChI	1S/C10H12FN3/c1-7(12)6-14-10-4-9(11)3-2-8(10)5-13-14/h2-5,7H,6,12H2,1H3/t7-/m0/s1
InChIKey	OARAVURQNSHWSP-ZETCQYMHSA-N
PubChem Compound ID	9859429
Target and Pathway
Target(s)	5-hydroxytryptamine 2C receptor	Target Info	Inhibitor	[529168]
	5-hydroxytryptamine 2A receptor	Target Info	Inhibitor	[529168]
KEGG Pathway	Calcium signaling pathway
	Neuroactive ligand-receptor interaction
	Gap junction
	Serotonergic synapse
	Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
	Inflammatory mediator regulation of TRP channels
PANTHER Pathway	5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome	Serotonin receptors
	G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
	G alpha (q) signalling events
WikiPathways	Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
	Monoamine GPCRs
	GPCRs, Class A Rhodopsin-like
	Gastrin-CREB signalling pathway via PKC and MAPK
	GPCR ligand binding
	GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
	SIDS Susceptibility Pathways
	GPCR downstream signaling
	GPCRs, Other
References
Ref 529168	Bioorg Med Chem. 2008 Feb 15;16(4):1966-82. Epub 2007 Nov 4.Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists.
Ref 529168	Bioorg Med Chem. 2008 Feb 15;16(4):1966-82. Epub 2007 Nov 4.Synthesis and structure-activity relationships of a series of substituted 2-(1H-furo[2,3-g]indazol-1-yl)ethylamine derivatives as 5-HT2C receptor agonists.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.