Drug Information

Drug General Information
Drug ID
D05KBP
Former ID
DIB001403
Drug Name
INO-8875
Synonyms
PJ-875; Adenosine A1 agonist (atrial fibrillation), Inotek; Adenosine A1 agonist (glaucoma), Inotek
Indication Glaucoma [ICD9: 365; ICD10:H40-H42] Phase 1/2 [523044]
Company
Inotek pharmaceuticals
Structure
Download
2D MOL

3D MOL
Canonical SMILES
C1CCCC1Nc1ncnc2n([C@H]3[C@H](O)[C@H](O)[C@@H](CO[N+](=O<br />)[O-])O3)cnc12
Target and Pathway
Target(s) Adenosine A1 receptor Target Info Agonist [532076]
KEGG Pathway cGMP-PKG signaling pathway
cAMP signaling pathway
Sphingolipid signaling pathway
Neuroactive ligand-receptor interaction
Morphine addiction
NetPath Pathway TCR Signaling Pathway
RANKL Signaling Pathway
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Heterotrimeric G-protein signaling pathway-Gq alpha and Go alpha mediated pathway
Reactome Adenosine P1 receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signaling
References
Ref 523044ClinicalTrials.gov (NCT01123785) A Dose-Escalation Study Designed to Evaluate the Tolerability, Safety, Pharmacokinetics (PK), and Efficacy of Chronic Topical Ocular Application of INO-8875 in AdultsWith Ocular Hypertension or Primary Open-Angle Glaucoma. U.S. National Institutes of Health.
Ref 532076INO-8875, a highly selective A1 adenosine receptor agonist: evaluation of chronotropic, dromotropic, and hemodynamic effects in rats. J Pharmacol Exp Ther. 2013 Jan;344(1):59-67.

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