Drug Information
| Drug General Information | |||||
|---|---|---|---|---|---|
| Drug ID |
D05MQK
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| Former ID |
DAP000615
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| Drug Name |
Tadalafil
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| Synonyms |
ADCIRCA; Acdirca; Cialis; Tadanafil; Lilly brand of tadalafil; Tadalafil [USAN]; GF 196960; IC 351; ICOS 351; Ic351; Cialis (TN); GF-196960; IC-351; KS-1117; Tadalafil (JAN/USAN/INN); Cialis, GF 196960, IC 351, ICOS 351, Tadalafil; (6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-(methylenedioxy)phenyl) pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione; (6R,12aR)-2,3,6,7,12,12a-Hexahydro-2-methyl-6-(3,4-methylenedioxyphenyl)pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione; (6R-trans)-6-(1,3-Benzodioxol-5-yl)-2,3,6,7,12,12a-hexahydro-2-methyl-pyrazino(1',2':1,6)pyrido(3,4-b)indole-1,4-dione
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| Drug Type |
Small molecular drug
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| Therapeutic Class |
Antiimpotence Agents
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| Company |
Eli Lilly
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| Structure |
|
Download2D MOL |
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| Formula |
C22H19N3O4
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| InChI |
InChI=1S/C22H19N3O4/c1-24-10-19(26)25-16(22(24)27)9-14-13-4-2-3-5-15(13)23-20(14)21(25)12-6-7-17-18(8-12)29-11-28-17/h2-8,16,21,23H,9-11H2,1H3/t16-,21-/m1/s1
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| InChIKey |
WOXKDUGGOYFFRN-IIBYNOLFSA-N
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| CAS Number |
CAS 171596-29-5
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| PubChem Compound ID | |||||
| PubChem Substance ID |
585746, 833257, 7849070, 7980303, 10235225, 12015128, 14756405, 14805118, 26719828, 44439099, 46386604, 46393582, 46507646, 46515102, 48631155, 49665805, 49666420, 49681754, 50070180, 50070554, 50071306, 50930588, 53789230, 57338564, 71826083, 92308507, 103205141, 104253184, 104386552, 118046114, 124658965, 124757304, 124801305, 124976968, 125164108, 126670668, 126730649, 129612837, 131407413, 134337906, 134358339, 135067956, 137002812, 142183965, 144075910, 144206195, 152031978, 152344458, 160709391, 160821591
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| SuperDrug ATC ID |
G04BE08
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| SuperDrug CAS ID |
cas=171596295
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| Target and Pathway | |||||
| Target(s) | CGMP-specific 3',5'-cyclic phosphodiesterase | Target Info | Inhibitor | [535487], [535643], [537402] | |
| KEGG Pathway | Purine metabolism | ||||
| cGMP-PKG signaling pathway | |||||
| NetPath Pathway | TGF_beta_Receptor Signaling Pathway | ||||
| Reactome | cGMP effects | ||||
| References | |||||
| Ref 536493 | Designing drugs for the treatment of female sexual dysfunction. Drug Discov Today. 2007 Sep;12(17-18):757-66. Epub 2007 Aug 27. | ||||
| Ref 542319 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7299). | ||||
| Ref 535487 | Tadalafil (Cialis) for men with erectile dysfunction. Int J Clin Pract. 2002 May;56(4):300-4. | ||||
| Ref 535643 | Phosphodiesterase type 5 inhibitors for the treatment of erectile dysfunction in patients with diabetes mellitus. Int J Impot Res. 2002 Dec;14(6):466-71. | ||||
| Ref 537402 | Pulmonary arterial hypertension: the most devastating vascular complication of systemic sclerosis. Rheumatology (Oxford). 2009 Jun;48 Suppl 3:iii25-31. | ||||
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