Drug Information

Drug General Information
Drug ID
D05NOS
Former ID
DAP000294
Drug Name
Triflupromazine
Synonyms
Adazine; Fluopromazine; Fluorofen; Neoprin; Nivoman; Psyquil; Siquil; Trifluopromazine; Triflupromazina; Triflupromazinum;Vesprin; Vetame; Fluopromazine monohydrochloride; Trifluopromazine hydrochloride; Triflupromazine [INN]; Triflupromazina [INN-Spanish]; Triflupromazinum [INN-Latin]; Vesprin (TN); Triflupromazine (USP/INN); N,N-Dimethyl-2-(trifluoromethyl)-10H-phenothiazine-10-propanamine; N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine; N,N-dimethyl-3-[2-(trifluoromethyl)phenothiazin-10-yl]propan-1-amine hydrochloride; N,N-dimethyl-3-[2-(trifluoromethyl)-10H-phenothiazin-10-yl]propan-1-amine; N,N-dimethyl-3-(2-(trifluoromethyl)-10H-phenothiazin-10-yl)-1-propanamine; 10-(3-(Dimethylamino)propyl)-2-(trifluoromethyl)phenothiazine; 10-3-(Dimethylamino)propyl-2-(trifluoromethyl)phenothiazine; 2-(Trifluoromethyl)promazine; 2-Trifluoromethyl-10-(gamma-dimethylaminopropyl)phenothiazine
Drug Type
Small molecular drug
Indication Psychoses [ICD9: 290-299; ICD10:F20-F29] Approved [467669], [538443]
Therapeutic Class
Antipsychotic Agents
Company
Bristol-Myers Squibb
Structure
Download
2D MOL

3D MOL
Formula
C18H19F3N2S
InChI
InChI=1S/C18H19F3N2S/c1-22(2)10-5-11-23-14-6-3-4-7-16(14)24-17-9-8-13(12-15(17)23)18(19,20)21/h3-4,6-9,12H,5,10-11H2,1-2H3
InChIKey
XSCGXQMFQXDFCW-UHFFFAOYSA-N
CAS Number
CAS 146-54-3
PubChem Compound ID
5568
PubChem Substance ID
5664289, 7847456, 8153424, 10508360, 11111873, 11111874, 11335983, 11361222, 11362929, 11365491, 11368053, 11374201, 11376215, 11405424, 11405821, 11462194, 11466081, 11467201, 11485862, 11492556, 11493909, 14925496, 24263033, 29224607, 46507344, 47365232, 47440302, 47440303, 47662324, 47662325, 47736524, 48035163, 48259273, 48259274, 48334534, 48416663, 49698933, 50006493, 50100355, 50104262, 50839748, 56394865, 57322847, 85209834, 90341005, 103024193, 103179080, 103841663, 103957782, 104309608
ChEBI ID
ChEBI:9711
SuperDrug ATC ID
N05AA05
SuperDrug CAS ID
cas=000146543
Target and Pathway
Target(s) 5-hydroxytryptamine 2B receptor Target Info Antagonist [537770]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signaling
References
Ref 467669(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 4330).
Ref 538443FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 011123.
Ref 537770Some properties of 5-hydroxytryptamine receptors in the hindquarters of the rat. Br J Pharmacol. 1979 Sep;67(1):79-85.

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