Drug Information

Drug General Information
Drug ID
D05NSP
Former ID
DNC007348
Drug Name
GNF-PF-4599
Drug Type
Small molecular drug
Indication Discovery agent Investigative [528504]
Structure
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2D MOL

3D MOL
Formula
C24H29F3N4O3
Canonical SMILES
CC1CC(CN(C1)CCCNC2=C(C=C(C=C2)C(=O)NC3=CC=C(C=C3)C(F)(F<br />)F)[N+](=O)[O-])C
InChI
1S/C24H29F3N4O3/c1-16-12-17(2)15-30(14-16)11-3-10-28-21-9-4-18(13-22(21)31(33)34)23(32)29-20-7-5-19(6-8-20)24(25,26)27/h4-9,13,16-17,28H,3,10-12,14-15H2,1-2H3,(H,29,32)
InChIKey
VWDZICDNGXUIKB-UHFFFAOYSA-N
PubChem Compound ID
44422654
Target and Pathway
Target(s) Voltage-dependent T-type calcium channel subunit alpha-1H Target Info Inhibitor [528504]
KEGG Pathway MAPK signaling pathway
Calcium signaling pathway
Circadian entrainment
PathWhiz Pathway Muscle/Heart Contraction
Reactome NCAM1 interactions
WikiPathways Corticotropin-releasing hormone
NCAM signaling for neurite out-growth
References
Ref 528504Bioorg Med Chem. 2007 Jan 15;15(2):1091-105. Epub 2006 Oct 30.3D pharmacophore based virtual screening of T-type calcium channel blockers.
Ref 528504Bioorg Med Chem. 2007 Jan 15;15(2):1091-105. Epub 2006 Oct 30.3D pharmacophore based virtual screening of T-type calcium channel blockers.

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