Drug Information

Drug General Information
Drug ID
D05NWF
Former ID
DIB018757
Drug Name
adenosine diphosphate
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539065]
Structure
Download
2D MOL
Formula
C10H15N5O10P2
InChI
InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1
InChIKey
XTWYTFMLZFPYCI-KQYNXXCUSA-N
PubChem Compound ID
6022
PubChem Substance ID
3310, 583708, 583773, 583911, 583921, 583922, 584175, 584188, 584204, 584229, 584302, 584513, 584515, 584599, 584626, 584627, 584628, 584632, 584641, 584643, 585456, 585517, 585721, 585872, 793510, 819880, 819957, 820163, 820296, 820360, 820365, 820433, 820439, 820507, 820515, 820541, 820600, 821195, 821592, 821838, 821868, 822043, 822090, 822091, 822116, 822129, 822159, 822163, 822165, 822167
Target and Pathway
Target(s) P2Y13 receptor Target Info Agonist [526649]
P2Y purinoceptor 1 Target Info Agonist [526444]
P2Y purinoceptor 6 Target Info Agonist [534141]
TRPM4 Target Info Inhibitor (gating inhibitor) [526954]
P2Y purinoceptor 12 Target Info Agonist [527109]
KEGG Pathway Rap1 signaling pathway
Neuroactive ligand-receptor interaction
Platelet activationhsa04080:Neuroactive ligand-receptor interactionhsa04611:Platelet activation
Reactome G alpha (q) signalling events
P2Y receptors
ADP signalling through P2Y purinoceptor 1R-HSA-416476:G alpha (q) signalling events
P2Y receptorsR-HSA-417957:P2Y receptors
G alpha (i) signalling events
WikiPathways Nucleotide GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Signal amplification
GPCR ligand binding
GPCR downstream signalingWP80:Nucleotide GPCRs
GPCR downstream signalingWP455:GPCRs, Class A Rhodopsin-like
GPCR downstream signaling
References
Ref 539065(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1712).
Ref 526444Quantitation of the P2Y(1) receptor with a high affinity radiolabeled antagonist. Mol Pharmacol. 2002 Nov;62(5):1249-57.
Ref 526649Pharmacological characterization of the human P2Y13 receptor. Mol Pharmacol. 2003 Jul;64(1):104-12.
Ref 526954Intracellular nucleotides and polyamines inhibit the Ca2+-activated cation channel TRPM4b. Pflugers Arch. 2004 Apr;448(1):70-5. Epub 2004 Jan 31.
Ref 527109P2Y12, a new platelet ADP receptor, target of clopidogrel. Semin Vasc Med. 2003 May;3(2):113-22.
Ref 534141Cloning, functional expression and tissue distribution of the human P2Y6 receptor. Biochem Biophys Res Commun. 1996 May 15;222(2):303-8.

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