Drug Information

Drug General Information
Drug ID
D05NWH
Former ID
DIB020904
Drug Name
SB 228357
Synonyms
SB-228357; SB228357
Drug Type
Small molecular drug
Indication Discovery agent Investigative [539221]
Structure
Download
2D MOL
Formula
C22H17F4N3O2
InChI
InChI=1S/C22H17F4N3O2/c1-31-20-9-13-4-6-29(19(13)11-18(20)22(24,25)26)21(30)28-17-8-15(7-16(23)10-17)14-3-2-5-27-12-14/h2-3,5,7-12H,4,6H2,1H3,(H,28,30)
InChIKey
RRJLJKRFFRZRAF-UHFFFAOYSA-N
PubChem Compound ID
443390
PubChem Substance ID
13907, 5751310, 10299304, 11111785, 11114049, 14905408, 17405182, 36886717, 50104826, 50104827, 51495386, 53777726, 56311665, 85209888, 85231222, 85788143, 92303930, 103176772, 103985462, 104629870, 124749863, 124881414, 124881415, 124881416, 129170841, 131302946, 134222385, 135650995, 135698235, 162022790, 162247314, 164759629, 174006602, 184565829, 196402246, 206248427, 223440904, 223468628, 232703967, 241182374, 241375391, 249614017, 252369967
Target and Pathway
Target(s) 5-hydroxytryptamine 2B receptor Target Info Antagonist [525730]
5-hydroxytryptamine 2A receptor Target Info Antagonist [525730]
5-hydroxytryptamine 2C receptor Target Info Antagonist [525730]
KEGG Pathway Calcium signaling pathway
Neuroactive ligand-receptor interaction
Gap junction
Serotonergic synapse
Inflammatory mediator regulation of TRP channelshsa04020:Calcium signaling pathway
Inflammatory mediator regulation of TRP channels
PANTHER Pathway 5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathwayP04374:5HT2 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (q) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (q) signalling events
WikiPathways Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
GPCR ligand binding
GPCR downstream signalingWP733:Serotonin Receptor 2 and STAT3 Signaling
SIDS Susceptibility Pathways
GPCR downstream signaling
GPCRs, OtherWP732:Serotonin Receptor 2 and ELK-SRF/GATA4 signaling
References
Ref 539221(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 192).
Ref 525730Biarylcarbamoylindolines are novel and selective 5-HT(2C) receptor inverse agonists: identification of 5-methyl-1-[[2-[(2-methyl-3-pyridyl)oxy]- 5-pyridyl]carbamoyl]-6-trifluoromethylindoline (SB-243213) as a potential antidepressant/anxiolytic agent. J Med Chem. 2000 Mar 23;43(6):1123-34.

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