Drug General Information
Drug ID
D05OQX
Former ID
DCL000892
Drug Name
NCX-4016
Synonyms
Nitroaspirin; Ncx 4016; NO-ASA; Nitric oxide-releasing aspirin; M-NO-ASA; M-NO-aspirin; [3-(nitrooxymethyl)phenyl] 2-acetyloxybenzoate; Benzoic acid, 2-(acetyloxy)-, 2-((nitrooxy)methyl)phenyl ester; Benzoic acid, 2-(acetyloxy)-, 3-((nitrooxy)methyl)phenyl ester; 2-((Nitrooxy)methyl)phenyl 2-(acetyloxy)benzoate; 2-Acetoxybenzoate-2-(1-nitroxymethyl)phenyl ester; 2-Acetoxybenzoic acid 3-(nitrooxymethyl)phenyl ester; 2-Acetoxybenzoic acid 3-nitrooxymethylphenyl ester; 3-((Nitrooxy)methyl)phenyl 2-(acetyloxy)benzoate; 3-(Nitroxymethyl)phenyl 2-acetoxybenzoate
Drug Type
Small molecular drug
Indication Inflammation [ICD10:E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89] Phase 2 [527729]
Type 2 diabetes; Early nephropathy; Claudication [ICD9: 250, 250.00, 250.02, 250.4, 338, 437.6, 443.9, 453, 580-599, 671.5, 671.9,780; ICD10:E08-E13, E10.2, E11, E11.2, E13.2, I73.9, I80-I82, N00-N29, G89] Discontinued in Phase 2 [536186]
Therapeutic Class
Analgesics
Company
NiCox SA
Structure
Download
2D MOL

3D MOL

Formula
C16H13NO7
Canonical SMILES
CC(=O)OC1=CC=CC=C1C(=O)OC2=CC=CC(=C2)CO[N+](=O)[O-]
InChI
1S/C16H13NO7/c1-11(18)23-15-8-3-2-7-14(15)16(19)24-13-6-4-5-12(9-13)10-22-17(20)21/h2-9H,10H2,1H3
InChIKey
IOJUJUOXKXMJNF-UHFFFAOYSA-N
CAS Number
CAS 175033-36-0
PubChem Compound ID
PubChem Substance ID
Target and Pathway
Target(s) Cyclooxygenase Target Info Inhibitor [536186]
References
Ref 527729Direct and irreversible inhibition of cyclooxygenase-1 by nitroaspirin (NCX 4016). J Pharmacol Exp Ther. 2005 Dec;315(3):1331-7. Epub 2005 Sep 6.
Ref 536186Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90.
Ref 536186Emerging drugs in peripheral arterial disease. Expert Opin Emerg Drugs. 2006 Mar;11(1):75-90.

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