Drug Information

Drug General Information
Drug ID
D05PYO
Former ID
DIB018902
Drug Name
aspirin-triggered resolvin D1
Synonyms
AT-Resolvin D1; AT-RvD1
Drug Type
Small molecular drug
Indication Discovery agent Investigative [541408]
Structure
Download
2D MOL
Formula
C22H32O5
InChI
InChI=1S/C22H32O5/c1-2-3-9-14-19(23)15-10-6-4-5-7-11-16-20(24)21(25)17-12-8-13-18-22(26)27/h3-12,15-16,19-21,23-25H,2,13-14,17-18H2,1H3,(H,26,27)/b6-4-,7-5+,9-3-,12-8-,15-10+,16-11+/t19-,20-,21+/m1/s1
InChIKey
OIWTWACQMDFHJG-BJEBZIPWSA-N
PubChem Compound ID
16126783
PubChem Substance ID
40660646, 46542480, 103619464, 126522562, 178102860, 237739855, 252465959
Target and Pathway
Target(s) FMLP-related receptor I Target Info Agonist [531857]
Transient receptor potential cation channel subfamily V member 3 Target Info Blocker (channel blocker) [531538]
KEGG Pathway Inflammatory mediator regulation of TRP channels
Pathway Interaction Database Urokinase-type plasminogen activator (uPA) and uPAR-mediated signaling
Reactome G alpha (q) signalling events
G alpha (i) signalling eventsR-HSA-3295583:TRP channels
WikiPathways GPCRs, Class A Rhodopsin-like
Gastrin-CREB signalling pathway via PKC and MAPK
Peptide GPCRs
GPCR ligand binding
GPCR downstream signaling
References
Ref 541408(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6239).
Ref 53153817(R)-resolvin D1 specifically inhibits transient receptor potential ion channel vanilloid 3 leading to peripheral antinociception. Br J Pharmacol. 2012 Feb;165(3):683-92.
Ref 531857Resolvin D1 receptor stereoselectivity and regulation of inflammation and proresolving microRNAs. Am J Pathol. 2012 May;180(5):2018-27.

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