Drug Information

Drug General Information
Drug ID
D05REB
Former ID
DIB005851
Drug Name
ZT-1
Synonyms
(5R,9R)-5-(5-Chloro-2-hydroxy-3-methoxybenzylideneamino)-11-ethylidene-7-methyl-1,2,5,6,9,10-hexahydro-5,9-methanocycloocta[b]pyridin-2-one; 180694-97-7
Drug Type
Small molecular drug
Indication Parkinson's disease [ICD9: 332; ICD10:G20] Phase 1 [532328]
Structure
Download
2D MOL

3D MOL
Formula
C23H23ClN2O3
Canonical SMILES
CC=C1C2CC3=C(C1(CC(=C2)C)NC=C4C=C(C=C(C4=O)OC)Cl)C=CC(=<br />O)N3
InChI
1S/C23H23ClN2O3/c1-4-17-14-7-13(2)11-23(17,18-5-6-21(27)26-19(18)9-14)25-12-15-8-16(24)10-20(29-3)22(15)28/h4-8,10,12,14,25H,9,11H2,1-3H3,(H,26,27)/b15-12-,17-4+
InChIKey
GYTJFKCCTYZWGL-WQOXWKGMSA-N
CAS Number
CAS 180694-97-7
PubChem Compound ID
44153604
PubChem Substance ID
135262442
Target and Pathway
Target(s) Acetylcholinesterase Target Info Inhibitor [527018], [551871]
KEGG Pathway Glycerophospholipid metabolism
Cholinergic synapse
PANTHER Pathway Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Muscarinic acetylcholine receptor 2 and 4 signaling pathway
Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database ATF-2 transcription factor network
PathWhiz Pathway Phospholipid Biosynthesis
WikiPathways Monoamine Transport
Biogenic Amine Synthesis
Acetylcholine Synthesis
Integrated Pancreatic Cancer Pathway
References
Ref 532328Phase I study on the pharmacokinetics and tolerance of ZT-1, a prodrug of huperzine A, for the treatment of Alzheimer's disease. Acta Pharmacol Sin. 2013 Jul;34(7):976-82.
Ref 527018A sensitive method for the determination of the novel cholinesterase inhibitor ZT-1 and its active metabolite huperzine A in rat blood using liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom. 2004;18(6):651-6.
Ref 551871Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015

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