Drug Information

Drug General Information
Drug ID
D05RRK
Former ID
DNC012980
Drug Name
Phe-Pro-Glu
Drug Type
Small molecular drug
Indication Discovery agent Investigative [527903]
Structure
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2D MOL

3D MOL
Formula
C19H25N3O6
Canonical SMILES
C1CC(N(C1)C(=O)C(CC2=CC=CC=C2)N)C(=O)NC(CCC(=O)O)C(=O)O
InChI
1S/C19H25N3O6/c20-13(11-12-5-2-1-3-6-12)18(26)22-10-4-7-15(22)17(25)21-14(19(27)28)8-9-16(23)24/h1-3,5-6,13-15H,4,7-11,20H2,(H,21,25)(H,23,24)(H,27,28)/t13-,14-,15-/m0/s1
InChIKey
QARPMYDMYVLFMW-KKUMJFAQSA-N
PubChem Compound ID
44408683
Target and Pathway
Target(s) NMDA receptor subunit NR1 Target Info Inhibitor [527903]
Glutamate [NMDA] receptor subunit epsilon 1 Target Info Inhibitor [527903]
Glutamate [NMDA] receptor subunit epsilon 2 Target Info Inhibitor [527903]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Cocaine addiction
Amphetamine addiction
Nicotine addiction
Alcoholismhsa04014:Ras signaling pathway
Dopaminergic synapse
Alcoholism
Systemic lupus erythematosushsa04014:Ras signaling pathway
Systemic lupus erythematosus
PANTHER Pathway Huntington disease
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathwayP00029:Huntington disease
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database Reelin signaling pathwayerbb4_pathway:ErbB4 signaling events
Reelin signaling pathway
Reactome EPHB-mediated forward signaling
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
RAF/MAP kinase cascadeR-HSA-438066:Unblocking of NMDA receptor, glutamate binding and activation
RAF/MAP kinase cascadeR-HSA-3928662:EPHB-mediated forward signaling
RAF/MAP kinase cascade
WikiPathways SIDS Susceptibility Pathways
Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
Spinal Cord Injury
BDNF signaling pathway
Alzheimers DiseaseWP666:Hypothetical Network for Drug Addiction
References
Ref 527903Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6.New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity.
Ref 527903Bioorg Med Chem Lett. 2006 Mar 1;16(5):1392-6.New Gly-Pro-Glu (GPE) analogues: expedite solid-phase synthesis and biological activity.

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