Drug Information

Drug General Information
Drug ID
D05SHK
Former ID
DAP000122
Drug Name
Nadolol
Synonyms
Anabet; Corgard; Corgaretic; Nadic; Nadololum; Solgol; SQ 11725; SQ11725; Anabet (TN); Corgard (TN); Corzide (TN); Nadololum [INN-Latin]; SQ-11725; Solgol (TN); Alti-Nadolol (TN); Apo-Nadol (TN); Novo-Nadolol (TN); Nadolol (JP15/USP/INN); Nadolol [USAN:BAN:INN:JAN]; (2R,3S)-5-(3-(tert-Butylamino)-2-hydroxypropoxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol; (2R,3S)-5-({3-[(1,1-dimethylethyl)amino]-2-hydroxypropyl}oxy)-1,2,3,4-tetrahydronaphthalene-2,3-diol; (2R,3S)-5-[3-(tert-butylamino)-2-hydroxypropoxy]-1,2,3,4-tetrahydronaphthalene-2,3-diol; 2,3-cis-1,2,3,4-Tetrahydro-5-((2-hydroxy-3-tert-butylamino)propoxy)-2,3-naphthalenediol; 5-(3-((1,1-Dimethylethyl)amino)-2-hydroxypropoxy)-1,2,3,4-tetrahydro-2,3-naphthalenediol
Drug Type
Small molecular drug
Indication High blood pressure; Angina [ICD9: 401, 413; ICD10:I10, I11, I12, I13, I15, I20] Approved [538266], [540927]
Therapeutic Class
Antihypertensive Agents
Company
Apotex Inc
Structure
Download
2D MOL

3D MOL
Formula
C17H27NO4
InChI
InChI=1S/C17H27NO4/c1-17(2,3)18-9-12(19)10-22-16-6-4-5-11-7-14(20)15(21)8-13(11)16/h4-6,12,14-15,18-21H,7-10H2,1-3H3/t12?,14-,15+/m1/s1
InChIKey
VWPOSFSPZNDTMJ-UCWKZMIHSA-N
CAS Number
CAS 42200-33-9
PubChem Compound ID
39147
PubChem Substance ID
855594, 7847498, 7980059, 8149963, 8175898, 10321209, 11335602, 11360841, 11364537, 11367099, 11369661, 11372751, 11373904, 11377823, 11461813, 11466846, 11467966, 11485128, 11486372, 11489362, 11491401, 11492008, 11495457, 12013396, 26612453, 26680146, 34705082, 46505509, 47216720, 47440192, 47515259, 48035045, 48110397, 48416301, 49995587, 50105273, 53787811, 56413054, 56422422, 57312272, 75643004, 85787107, 92124849, 92125681, 92307845, 99301515, 99351138, 103189209, 103913689, 104169962
ChEBI ID
ChEBI:7444
SuperDrug ATC ID
C07AA12
SuperDrug CAS ID
cas=042200339
Target and Pathway
Target(s) Beta-1 adrenergic receptor Target Info Modulator [556264]
KEGG Pathway Calcium signaling pathway
cGMP-PKG signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Endocytosis
Adrenergic signaling in cardiomyocytes
Gap junction
Salivary secretion
Dilated cardiomyopathy
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
Beta1 adrenergic receptor signaling pathway
PathWhiz Pathway Muscle/Heart Contraction
Reactome Adrenoceptors
G alpha (s) signalling events
WikiPathways Monoamine GPCRs
Calcium Regulation in the Cardiac Cell
GPCRs, Class A Rhodopsin-like
Endothelin Pathways
GPCR ligand binding
GPCR downstream signaling
References
Ref 538266FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (ANDA) 074229.
Ref 540927(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 554).
Ref 556264Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.

If You Find Any Error in Data or Bug in Web Service, Please Kindly Report It to Dr. Zhou and Dr. Zhang.