Drug General Information
Drug ID	D05UHJ
Former ID	DIB016307
Drug Name	SM-10888
Indication	Cognitive disorders [ICD9: 290-294, 294.0, 780.09, 780.9, 780.93; ICD10:F01-F07, F04, F05, R41.3]		Discontinued in Phase 2	[544850]
Company	Sumitomo Pharmaceuticals Co Ltd
Structure		Download 2D MOL 3D MOL
Formula	C54H55F3N6O14
Canonical SMILES	c12c(nc3c(c1N)c(F)ccc3)C1CC(C2)C1.C(CC(=O)O)(CC(=O)O)(C<br />(=O)O)O
CAS Number	CAS 116208-23-2
PubChem Compound ID	196829
Target and Pathway
Target(s)	Acetylcholinesterase	Target Info	Inhibitor	[532426]
KEGG Pathway	Glycerophospholipid metabolism
	Cholinergic synapse
PANTHER Pathway	Muscarinic acetylcholine receptor 1 and 3 signaling pathway
	Muscarinic acetylcholine receptor 2 and 4 signaling pathway
	Nicotinic acetylcholine receptor signaling pathway
Pathway Interaction Database	ATF-2 transcription factor network
PathWhiz Pathway	Phospholipid Biosynthesis
WikiPathways	Monoamine Transport
	Biogenic Amine Synthesis
	Acetylcholine Synthesis
	Integrated Pancreatic Cancer Pathway
References
Ref 544850	Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800001320)
Ref 532426	Pharmacological and biochemical assessment of SM-10888, a novel cholinesterase inhibitor. Jpn J Pharmacol. 1990 Jun;53(2):145-55.

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