Drug General Information
Drug ID
D05ZQO
Former ID
DNC013450
Drug Name
N-(3-phenethoxybenzyl)-4-hydroxybenzamide
Drug Type
Small molecular drug
Indication Discovery agent Investigative [529014]
Structure
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2D MOL

3D MOL

Formula
C22H21NO3
Canonical SMILES
C1=CC=C(C=C1)CCOC2=CC=CC(=C2)CNC(=O)C3=CC=C(C=C3)O
InChI
1S/C22H21NO3/c24-20-11-9-19(10-12-20)22(25)23-16-18-7-4-8-21(15-18)26-14-13-17-5-2-1-3-6-17/h1-12,15,24H,13-14,16H2,(H,23,25)
InChIKey
VZKHCMVEWLIXIC-UHFFFAOYSA-N
PubChem Compound ID
Target and Pathway
Target(s) Glutamate [NMDA] receptor subunit epsilon 2 Target Info Inhibitor [529014]
KEGG Pathway Ras signaling pathway
Rap1 signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Circadian entrainment
Long-term potentiation
Glutamatergic synapse
Dopaminergic synapse
Alzheimer's disease
Amyotrophic lateral sclerosis (ALS)
Huntington's disease
Cocaine addiction
Amphetamine addiction
Nicotine addiction
Alcoholism
Systemic lupus erythematosus
PANTHER Pathway Huntington disease
Ionotropic glutamate receptor pathway
Metabotropic glutamate receptor group III pathway
Metabotropic glutamate receptor group I pathway
Muscarinic acetylcholine receptor 1 and 3 signaling pathway
Pathway Interaction Database ErbB4 signaling events
Reelin signaling pathway
Reactome EPHB-mediated forward signaling
Unblocking of NMDA receptor, glutamate binding and activation
CREB phosphorylation through the activation of CaMKII
Ras activation uopn Ca2+ infux through NMDA receptor
RAF/MAP kinase cascade
WikiPathways Hypothetical Network for Drug Addiction
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell
BDNF signaling pathway
References
Ref 529014Bioorg Med Chem Lett. 2007 Oct 15;17(20):5537-42. Epub 2007 Aug 19.Structure-activity relationship study of novel NR2B-selective antagonists with arylamides to avoid reactive metabolites formation.
Ref 529014Bioorg Med Chem Lett. 2007 Oct 15;17(20):5537-42. Epub 2007 Aug 19.Structure-activity relationship study of novel NR2B-selective antagonists with arylamides to avoid reactive metabolites formation.

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