Drug Information

Drug General Information
Drug ID
D06DZI
Former ID
DNC003505
Drug Name
GR-127935
Drug Type
Small molecular drug
Indication Major depressive disorder [ICD9: 296.2, 296.3, 710.0; ICD10:F32, F33, M32] Terminated [538876], [545301]
Structure
Download
2D MOL

3D MOL
Formula
C29H31N5O3
InChI
InChI=1S/C29H31N5O3/c1-19-17-23(28-30-20(2)37-32-28)9-11-25(19)21-5-7-22(8-6-21)29(35)31-24-10-12-27(36-4)26(18-24)34-15-13-33(3)14-16-34/h5-12,17-18H,13-16H2,1-4H3,(H,31,35)
InChIKey
YDBCEBYHYKAFRX-UHFFFAOYSA-N
PubChem Compound ID
107780
PubChem Substance ID
7361807, 7979276, 10234434, 11111230, 11114099, 14908719, 44436737, 47500600, 47574454, 47647601, 49894171, 50104861, 53788924, 57338245, 79039682, 85209088, 85787609, 90340955, 91704291, 103046600, 103178924, 103984442, 104379719, 124750000, 124880216, 124880217, 124880218, 125748894, 129778270, 134340710, 135066838, 135610571, 135650312, 135697554, 144240003, 152254722, 160830080, 162221927, 163094387, 163394389, 163843137, 172907935, 179235759, 184527350, 184538716, 198985096, 204365925, 223532823, 224977084, 233367607
Target and Pathway
Target(s) 5-hydroxytryptamine 1B receptor Target Info Modulator
5-hydroxytryptamine 1D receptor Target Info Modulator
KEGG Pathway cAMP signaling pathway
Neuroactive ligand-receptor interaction
Serotonergic synapsehsa04024:cAMP signaling pathway
Serotonergic synapse
PANTHER Pathway Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathwayP00026:Heterotrimeric G-protein signaling pathway-Gi alpha and Gs alpha mediated pathway
5HT1 type receptor mediated signaling pathway
Reactome Serotonin receptors
G alpha (i) signalling eventsR-HSA-390666:Serotonin receptors
G alpha (i) signalling events
WikiPathways Serotonin HTR1 Group and FOS Pathway
Monoamine GPCRs
GPCRs, Class A Rhodopsin-like
GPCR ligand binding
GPCR downstream signalingWP722:Serotonin HTR1 Group and FOS Pathway
GPCR downstream signaling
References
Ref 538876(http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 14).
Ref 545301Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800002743)

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