Drug General Information |
Drug ID |
D06EIC
|
Former ID |
DIB009252
|
Drug Name |
ASP-015K
|
Drug Type |
Small molecular drug
|
Indication |
Psoriasis [ICD9: 696; ICD10:L40]
|
Phase 3 |
[1],
[2]
|
Company |
Astellas Pharma Inc
|
Structure |
|
Download
2D MOL
|
Formula |
C18H22N4O2
|
InChI |
InChI=1S/C18H22N4O2/c19-16(23)13-8-21-17-12(1-2-20-17)15(13)22-14-10-3-9-4-11(14)7-18(24,5-9)6-10/h1-2,8-11,14,24H,3-7H2,(H2,19,23)(H2,20,21,22)/t9?,10-,11+,14?,18?
|
InChIKey |
DREIJXJRTLTGJC-JQCLMNFQSA-N
|
PubChem Compound ID |
|
PubChem Substance ID |
137951042, 137951123, 164180739, 173334224, 194147758, 227392433, 227392436, 230374902, 235335272, 235335280, 244451093, 245539868, 246562931, 252166527
|
Target and Pathway |
Target(s) |
Tyrosine-protein kinase JAK3 |
Target Info |
Inhibitor |
[3]
|
JAK1 |
Target Info |
Inhibitor |
[4]
|
KEGG Pathway
|
Chemokine signaling pathway
|
PI3K-Akt signaling pathway
|
Signaling pathways regulating pluripotency of stem cells
|
Jak-STAT signaling pathway
|
Measles
|
HTLV-I infection
|
Epstein-Barr virus infection
|
Viral carcinogenesis
|
Primary immunodeficiencyhsa04151:PI3K-Akt signaling pathway
|
Osteoclast differentiation
|
Leishmaniasis
|
Toxoplasmosis
|
Tuberculosis
|
Hepatitis C
|
Hepatitis B
|
Influenza A
|
Herpes simplex infection
|
Pathways in cancer
|
Pancreatic cancer
|
NetPath Pathway
|
IL2 Signaling Pathway
|
PANTHER Pathway
|
Interleukin signaling pathway
|
JAK/STAT signaling pathway
|
PDGF signaling pathwayP00005:Angiogenesis
|
Interferon-gamma signaling pathway
|
PDGF signaling pathway
|
Pathway Interaction Database
|
IL4-mediated signaling events
|
CD40/CD40L signaling
|
Signaling events mediated by TCPTP
|
SHP2 signaling
|
IL2-mediated signaling events
|
IL2 signaling events mediated by PI3K
|
IL2 signaling events mediated by STAT5p73pathway:p73 transcription factor network
|
IL27-mediated signaling events
|
IFN-gamma pathway
|
IL6-mediated signaling events
|
PDGFR-alpha signaling pathway
|
IL2 signaling events mediated by STAT5
|
Reactome
|
GPVI-mediated activation cascade
|
Interleukin-7 signaling
|
G beta:gamma signalling through PI3Kgamma
|
Interleukin-2 signaling
|
RAF/MAP kinase cascade
|
Interleukin receptor SHC signalingR-HSA-1059683:Interleukin-6 signaling
|
MAPK3 (ERK1) activation
|
MAPK1 (ERK2) activation
|
ISG15 antiviral mechanism
|
Interferon gamma signaling
|
Regulation of IFNG signaling
|
Interferon alpha/beta signaling
|
Interleukin receptor SHC signaling
|
Regulation of IFNA signaling
|
WikiPathways
|
IL-2 Signaling Pathway
|
IL-4 Signaling Pathway
|
Interleukin-2 signaling
|
Interleukin-7 signaling
|
Oncostatin M Signaling Pathway
|
IL-9 Signaling Pathway
|
IL-7 Signaling Pathway
|
Interleukin-3, 5 and GM-CSF signalingWP619:Type II interferon signaling (IFNG)
|
Interferon type I signaling pathways
|
TGF Beta Signaling Pathway
|
IL-6 signaling pathway
|
TCA Cycle Nutrient Utilization and Invasiveness of Ovarian Cancer
|
IL-3 Signaling Pathway
|
JAK/STAT
|
PDGF Pathway
|
Interleukin-11 Signaling Pathway
|
Prostate Cancer
|
TSLP Signaling Pathway
|
Type III interferon signaling
|
IL17 signaling pathway
|
Leptin signaling pathway
|
TSH signaling pathway
|
Integrated Breast Cancer Pathway
|
Integrated Cancer pathway
|
Interleukin-3, 5 and GM-CSF signaling
|
Interferon gamma signaling
|
Interferon alpha/beta signaling
|
IL-5 Signaling Pathway
|
References |
REF 1 | ClinicalTrials.gov (NCT02308163) A Study to Evaluate Safety and Efficacy of ASP015K in Patients With Rheumatoid Arthritis (RA) Who Had an Inadequate Response to DMARDs. U.S. National Institutes of Health. |
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REF 2 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8315). |
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REF 3 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2049). |
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REF 4 | (http://www.guidetopharmacology.org/) Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Target id: 2047). |