Drug Information

Drug General Information
Drug ID
D06ETD
Former ID
DNC011513
Drug Name
LUF-5437
Drug Type
Small molecular drug
Indication Discovery agent Investigative [526011]
Structure
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2D MOL

3D MOL
Formula
C15H11N3O2S
Canonical SMILES
C1=CC=C(C=C1)C2=NSC(=N2)NC(=O)C3=CC=C(C=C3)O
InChI
1S/C15H11N3O2S/c19-12-8-6-11(7-9-12)14(20)17-15-16-13(18-21-15)10-4-2-1-3-5-10/h1-9,19H,(H,16,17,18,20)
InChIKey
MIJWZALSSVTKAQ-UHFFFAOYSA-N
PubChem Compound ID
9994776
Target and Pathway
Target(s) Adenosine A2a receptor Target Info Inhibitor [526011]
KEGG Pathway Rap1 signaling pathway
Calcium signaling pathway
cAMP signaling pathway
Neuroactive ligand-receptor interaction
Vascular smooth muscle contraction
Parkinson's disease
Alcoholism
Pathway Interaction Database HIF-2-alpha transcription factor network
PathWhiz Pathway Intracellular Signalling Through Adenosine Receptor A2a and Adenosine
Reactome NGF-independant TRKA activation
Adenosine P1 receptors
G alpha (s) signalling events
Surfactant metabolism
WikiPathways Nucleotide GPCRs
Monoamine Transport
GPCRs, Class A Rhodopsin-like
NGF signalling via TRKA from the plasma membrane
GPCR ligand binding
GPCR downstream signaling
GPCRs, Other
References
Ref 526011J Med Chem. 2001 Mar 1;44(5):749-62.Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists.
Ref 526011J Med Chem. 2001 Mar 1;44(5):749-62.Thiazole and thiadiazole analogues as a novel class of adenosine receptor antagonists.

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